Evidence map›Paper›PMID 26398101›Full record

ArticlePloS one2015

Proteomic Alterations in B Lymphocytes of Sensitized Mice in a Model of Chemical-Induced Asthma.

Steven Haenen, Jeroen A J Vanoirbeek, Vanessa De Vooght, Liliane Schoofs, Benoit Nemery, Elke Clynen, Peter H M Hoet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Steven HaenenCentre for Environment and Health, KU Leuven, Leuven, Belgium; Research Group Functional Genomics and Proteomics, KU Leuven, Leuven, Belgium.
Jeroen A J VanoirbeekCentre for Environment and Health, KU Leuven, Leuven, Belgium.
Vanessa De VooghtCentre for Environment and Health, KU Leuven, Leuven, Belgium.
Liliane SchoofsResearch Group Functional Genomics and Proteomics, KU Leuven, Leuven, Belgium.
Benoit NemeryCentre for Environment and Health, KU Leuven, Leuven, Belgium.
Elke ClynenBiomedical Research Institute (BIOMED), Hasselt University, Hasselt, Belgium.
Peter H M HoetCentre for Environment and Health, KU Leuven, Leuven, Belgium.
KU Leuven · BEHasselt University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimThe role of B-lymphocytes in chemical-induced asthma is largely unknown. Recent work demonstrated that transferring B lymphocytes from toluene diisocyanate (TDI)-sensitized mice into naïve mice, B cell KO mice and SCID mice, triggered an asthma-like response in these mice after a subsequent TDI-challenge. We applied two-dimensional difference gel electrophoresis (2D-DIGE) to describe the "sensitized signature" of B lymphocytes comparing TDI-sensitized mice with control mice.

resultsSixteen proteins were identified that were significantly up- or down-regulated in B lymphocytes of sensitized mice. Particularly differences in the expression of cyclophilin A, cofilin 1 and zinc finger containing CCHC domain protein 11 could be correlated to the function of B lymphocytes as initiators of T lymphocyte independent asthma-like responses.

conclusionThis study revealed important alterations in the proteome of sensitized B cells in a mouse model of chemical-induced asthma, which will have an important impact on the B cell function.

Indexed as

AnimalsAsthmaB-LymphocytesMaleMice, Inbred BALB CMice, KnockoutMice, SCIDProteomeToluene 2,4-DiisocyanateProteomeToluene 2,4-Diisocyanate

Identifiers

PMID26398101
PMCPMC4580316
OpenAlexW2196940608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.