Trial reportThe New England journal of medicine2015
Intravascular Complications of Central Venous Catheterization by Insertion Site.
Trial report in The New England journal of medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 284 papers, 18 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Subclavian, Femoral and Internal Jugular Venous Catheterization in Term of Complications in the Intensive Care Unit: a Randomized Controlled Trial
Comparison of Bedside Ultrasound With Chest X-ray to Detect CVC Related Mechanical Complications; a Prospective Observational Study (COMBUX-study)
Daily Ultrasound-screening for CVC-related Thrombosis in Intensive Care Patients
Thrombotic Complications After Central Venous Catheterization: a Prospective Observational Study
A Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science in China
Observational Ultrasound Study of Subclavian Vein Anatomy: Comparison of Safety Margins Between Supraclavicular and Infraclavicular Positions According to Arm Position
Superior Venous Access: Single Lumen Midline Catheter vs Ultrasound Guided Peripheral IV as Performed by Bedside Emergency Department Registered Nurses, A Randomized Clinical Trial
Who cites it
284 citing papers in PubMed, 18 syntheses or guidelines pooled it, 762 citations in OpenAlex.
- Central venous cannulation in critically ill patients: guidelines of the Polish Society of Anaesthesiology and Intensive Therapy.Anaesthesiology intensive therapy · 2026Guideline
- Efficacy and safety of ultrasound-guided infraclavicular axillary vein cannulation for centrally inserted central catheter placement in critically ill patients: systematic review with meta-analysis and trial sequential analysis.Critical care (London, England) · 2026Pooled it
- Association of Anaesthetists guidelines: safe vascular access 2025.Anaesthesia · 2025Guideline
- Safety of peripheral intravenous administration of hypertonic saline: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Central venous catheter-related infections: a systematic review, meta-analysis, trial sequential analysis and meta-regression comparing ultrasound guidance and landmark technique for insertion.Critical care (London, England) · 2024Pooled it
- Systematic review of ultrasound-guided central venous catheter placement-related complications in neonates and infants aged <12 months.The Journal of international medical research · 2024Pooled it
- Complication Rates of Central Venous Catheters: A Systematic Review and Meta-Analysis.JAMA internal medicine · 2024Pooled it
- Venous Access: National Guideline and Registry Development (VANGUARD): Advancing Patient-Centered Venous Access Care Through the Development of a National Coordinated Registry Network.Journal of medical Internet research · 2023Guideline
- Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup.Critical care (London, England) · 2023Pooled it
- Incidence of catheter-related bloodstream infections following ultrasound-guided central venous catheterization: a systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.Clinical journal of the American Society of Nephrology : CJASN · 2022Pooled it
- Insertion site of central venous catheter among hospitalized adult patients: A systematic review and network meta-analysis.Frontiers in medicine · 2022Pooled it
- Central venous catheterization site choice based on anatomical landmark technique: a systematic review and meta-analysis.Journal of anesthesia · 2021Pooled it
- Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.Critical care (London, England) · 2021Pooled it
- Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis.Critical care (London, England) · 2021Pooled it
- Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline.Journal of diabetes science and technology · 2020Guideline
- Extracorporeal Treatment for Chloroquine, Hydroxychloroquine, and Quinine Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.Journal of the American Society of Nephrology : JASN · 2020Pooled it
- [Short-axisNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Pooled it
- Ultrasound-Guided In-Plane Subclavian Vein Puncture versus Prior Ultrasound and Landmark Technique: A Randomized Controlled Trial.Anesthesia and analgesia · 2026Trial
- Central venous versus short midline catheter in difficult intravenous access patients: a randomised clinical pilot trial.BMJ open · 2026Trial
224 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThree anatomical sites are commonly used to insert central venous catheters, but insertion at each site has the potential for major complications.
methodsIn this multicenter trial, we randomly assigned nontunneled central venous catheterization in patients in the adult intensive care unit (ICU) to the subclavian, jugular, or femoral vein (in a 1:1:1 ratio if all three insertion sites were suitable [three-choice scheme] and in a 1:1 ratio if two sites were suitable [two-choice scheme]). The primary outcome measure was a composite of catheter-related bloodstream infection and symptomatic deep-vein thrombosis.
resultsA total of 3471 catheters were inserted in 3027 patients. In the three-choice comparison, there were 8, 20, and 22 primary outcome events in the subclavian, jugular, and femoral groups, respectively (1.5, 3.6, and 4.6 per 1000 catheter-days; P=0.02). In pairwise comparisons, the risk of the primary outcome was significantly higher in the femoral group than in the subclavian group (hazard ratio, 3.5; 95% confidence interval [CI], 1.5 to 7.8; P=0.003) and in the jugular group than in the subclavian group (hazard ratio, 2.1; 95% CI, 1.0 to 4.3; P=0.04), whereas the risk in the femoral group was similar to that in the jugular group (hazard ratio, 1.3; 95% CI, 0.8 to 2.1; P=0.30). In the three-choice comparison, pneumothorax requiring chest-tube insertion occurred in association with 13 (1.5%) of the subclavian-vein insertions and 4 (0.5%) of the jugular-vein insertions.
conclusionsIn this trial, subclavian-vein catheterization was associated with a lower risk of bloodstream infection and symptomatic thrombosis and a higher risk of pneumothorax than jugular-vein or femoral-vein catheterization. (Funded by the Hospital Program for Clinical Research, French Ministry of Health; ClinicalTrials.gov number, NCT01479153.).
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.