ReviewCurrent opinion in rheumatology2015
Systemic sclerosis-associated fibrosis: an accelerated aging phenotype?
Review in Current opinion in rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial.JCI insight · 2022Trial
- Review
- Tertiary lymphoid structures and B-cell infiltration are IPF features with functional consequences.Frontiers in immunology · 2024Article
- Senescent Cells Accumulate in Systemic Sclerosis Skin.The Journal of investigative dermatology · 2023Article
- Upcoming treatments for morphea.Immunity, inflammation and disease · 2021Review
- TFAM-deficient mouse skin fibroblasts - an ex vivo model of mitochondrial dysfunction.Disease models & mechanisms · 2021Article
- Review
- Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma.Current rheumatology reports · 2020Review
- The natural history of progressive fibrosing interstitial lung diseases.The European respiratory journal · 2020Article
- Age-dependent dysregulation of redox genes may contribute to fibrotic pulmonary disease susceptibility.Free radical biology & medicine · 2019Article
- Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Sirtuins and Accelerated Aging in Scleroderma.Current rheumatology reports · 2018Review
- Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Accelerated and accentuated neurocognitive aging in HIV infection.Journal of neurovirology · 2017Article
- Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.Translational research : the journal of laboratory and clinical medicine · 2017Article
- Measurement of Serum Klotho in Systemic Sclerosis.Disease markers · 2017Article
- Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.Clinical epigenetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewSystemic sclerosis (SSc) is an autoimmune disease with fibrosis seen in multiple organs. Although not traditionally regarded as a disease of aging, SSc-associated fibrosis shares many of the hallmarks of aging seen in other age-related fibrotic disorders. Here, we review the current literature of the potential role of aging and age-related cellular processes in the development of SSc and fibrosis. RECENT
findingsAccumulating evidence supports a role for immune dysregulation, epigenetic modifications, cellular senescence, mitochondrial dysregulation and impaired autophagy in fibrosis that occurs in aging and SSc. SUMMARY: Cellular alterations linked to aging may promote the development and/or progression of SSc-associated fibrosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.