ArticlePain2016
Abnormal trigeminal sensory processing in obese mice.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Evaluation of the Effects of Eye Drops for Dry Eyes on Neuronal Pain Receptors in a Primary Culture Model of Trigeminal Ganglion Cells.Journal of clinical medicine · 2025Article
- Calcitonin gene-related peptide in newly diagnosed idiopathic intracranial hypertension: a prospective, cross-sectional, case-control study of cerebrospinal fluid and plasma.The journal of headache and pain · 2025Article
- Correlation Between Orofacial Pain and Sensory and Autonomic Neuropathies.Journal of pain research · 2024Article
- Assessing Orofacial Pain Behaviors in Animal Models: A Review.Brain sciences · 2023Review
- The impact of obesity-related raised intracranial pressure in rodents.Scientific reports · 2022Article
- Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension.The journal of headache and pain · 2021Review
- Association of Intranasal and Neurogenic Dural Inflammation in Experimental Acute Rhinosinusitis.Frontiers in pharmacology · 2020Article
- Body mass index and response to stereotactic radiosurgery in the treatment of refractory trigeminal neuralgia: A retrospective cohort study.Journal of radiosurgery and SBRT · 2020Article
- Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1.International journal of molecular sciences · 2019Review
- TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Peripheral Leptin Signaling Mediates Formalin-Induced Nociception.Neuroscience bulletin · 2018Article
- Leptin status alters buprenorphine-induced antinociception in obese mice with dysfunctional leptin receptors.Neuroscience letters · 2017Article
- Neuroendocrine signaling modulates specific neural networks relevant to migraine.Neurobiology of disease · 2017Article
- Female sex and obesity increase photophobic behavior in mice.Neuroscience · 2016Article
- Diet, body weight and pain susceptibility - A systematic review of preclinical studies.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Obesity is associated with several pain disorders including headache. The effects of obesity on the trigeminal nociceptive system, which mediates headache, remain unknown. We used 2 complementary mouse models of obesity (high-fat diet and leptin deficiency) to examine this. We assessed capsaicin-induced nocifensive behavior and photophobia in obese and control mice. Calcium imaging was used to determine the effects of obesity on the activity of primary trigeminal afferents in vitro. We found that obese mice had a normal acute response to a facial injection of capsaicin, but they developed photophobic behavior at doses that had no effect on control mice. We observed higher calcium influx in cultured trigeminal ganglia neurons from obese mice and a higher percentage of medium to large diameter capsaicin-responsive cells. These findings demonstrate that obesity results in functional changes in the trigeminal system that may contribute to abnormal sensory processing. Our findings provide the foundation for in-depth studies to improve the understanding of the effects of obesity on the trigeminal system and may have implications for the pathophysiology of headache disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.