ArticlePloS one2015
Genome-Wide Characterization and Expression Analysis of Major Intrinsic Proteins during Abiotic and Biotic Stresses in Sweet Orange (Citrus sinensis L. Osb.).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 98 citations in OpenAlex.
- Oil body membrane proteins as sensors of salt stress in sunflower seedlings: a proteomic insight.Plant signaling & behavior · 2025Article
- Major Intrinsic Proteins in Fungi: A Special Emphasis on the XIP Subfamily.Journal of fungi (Basel, Switzerland) · 2025Review
- Evolutionary and Structural Analysis of the Aquaporin Gene Family in Rice.Plants (Basel, Switzerland) · 2025Review
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- Genomic Survey of Genes Encoding Major Intrinsic Proteins (MIPs) and Their Response to Arsenite Stress in Pepper (Plants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification and Expression of theLife (Basel, Switzerland) · 2025Article
- Advances in the Structure, Function, and Regulatory Mechanism of Plant Plasma Membrane Intrinsic Proteins.Genes · 2024Review
- Osmolytes andFrontiers in plant science · 2024Article
- Combining Genetic and Transcriptomic Approaches to Identify Transporter-Coding Genes as Likely Responsible for a Repeatable Salt Tolerance QTL in Citrus.International journal of molecular sciences · 2023Article
- Exploring the role of HaTIPs genes in enhancing drought tolerance in sunflower.Molecular biology reports · 2023Article
- Actin-Depolymerizing Factor Gene Family Analysis Revealed ThatPlants (Basel, Switzerland) · 2023Article
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- Comprehensive meta-analysis of QTL and gene expression studies identify candidate genes associated withFrontiers in plant science · 2023Article
- Genome-Wide Identification and Expression Analyses of the Aquaporin Gene Family in Passion Fruit (International journal of molecular sciences · 2022Article
- The aquaporin gene PvXIP1;2 conferring drought resistance identified by GWAS at seedling stage in common bean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Comprehensive analysis of the GALACTINOL SYNTHASE (GolS) gene family in citrus and the function of CsGolS6 in stress tolerance.PloS one · 2022Article
- Differential regulation of drought stress by biological membrane transporters and channels.Plant cell reports · 2021Review
- Shared and tailored common bean transcriptomic responses to combined fusarium wilt and water deficit.Horticulture research · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The family of aquaporins (AQPs), or major intrinsic proteins (MIPs), includes integral membrane proteins that function as transmembrane channels for water and other small molecules of physiological significance. MIPs are classified into five subfamilies in higher plants, including plasma membrane (PIPs), tonoplast (TIPs), NOD26-like (NIPs), small basic (SIPs) and unclassified X (XIPs) intrinsic proteins. This study reports a genome-wide survey of MIP encoding genes in sweet orange (Citrus sinensis L. Osb.), the most widely cultivated Citrus spp. A total of 34 different genes encoding C. sinensis MIPs (CsMIPs) were identified and assigned into five subfamilies (CsPIPs, CsTIPs, CsNIPs, CsSIPs and CsXIPs) based on sequence analysis and also on their phylogenetic relationships with clearly classified MIPs of Arabidopsis thaliana. Analysis of key amino acid residues allowed the assessment of the substrate specificity of each CsMIP. Gene structure analysis revealed that the CsMIPs possess an exon-intron organization that is highly conserved within each subfamily. CsMIP loci were precisely mapped on every sweet orange chromosome, indicating a wide distribution of the gene family in the sweet orange genome. Investigation of their expression patterns in different tissues and upon drought and salt stress treatments, as well as with 'Candidatus Liberibacter asiaticus' infection, revealed a tissue-specific and coordinated regulation of the different CsMIP isoforms, consistent with the organization of the stress-responsive cis-acting regulatory elements observed in their promoter regions. A special role in regulating the flow of water and nutrients is proposed for CsTIPs and CsXIPs during drought stress, and for most CsMIPs during salt stress and the development of HLB disease. These results provide a valuable reference for further exploration of the CsMIPs functions and applications to the genetic improvement of both abiotic and biotic stress tolerance in citrus.
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