ArticleJournal of medicinal chemistry2015
Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation.
Article in Journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis.Inorganic chemistry · 2023Article
- Ru(II) CONTAINING PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY: A CRITIQUE ON REPORTING AND AN ATTEMPT TO COMPARE EFFICACY.Coordination chemistry reviews · 2022Article
- Copper(ii) curcumin complexes for endoplasmic reticulum targeted photocytotoxicity.RSC advances · 2022Article
- Novel Nickel(II), Palladium(II), and Platinum(II) Complexes withInternational journal of molecular sciences · 2022Article
- Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.International journal of molecular sciences · 2022Article
- Lysosomal Targeted Cyclometallic Iridium(Ⅲ) Salicylaldehyde-Coumarin Schiff Base Complexes and Anticancer Application.Frontiers in chemistry · 2022Article
- Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Article
- NMR studies of group 8 metallodrugs:Dalton transactions (Cambridge, England : 2003) · 2021Article
- Osmium-arene complexes with high potency towards Mycobacterium tuberculosis.Metallomics : integrated biometal science · 2021Article
- An intramolecular photoswitch can significantly promote photoactivation of Pt(iv) prodrugs.Chemical science · 2021Article
- Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice.Metallomics : integrated biometal science · 2021Article
- Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Metallodrugs are unique: opportunities and challenges of discovery and development.Chemical science · 2020Review
- Improvement of the Anticancer Activities of Telmisartan by Zn(II) Complexation and Mechanisms of Action.Biological trace element research · 2020Article
- Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells.Molecules (Basel, Switzerland) · 2019Review
- In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance.Journal of medicinal chemistry · 2018Article
- Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand.Molecules (Basel, Switzerland) · 2018Article
- Halide Control ofOrganometallics · 2017Article
- Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.Angewandte Chemie (International ed. in English) · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.