Evidence map›Paper›PMID 26397215›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2015

Micron-scale magnetic resonance imaging of both liquids and solids.

Eric Moore, Robert Tycko

Abstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Experimental demonstration of diffusion limitations on resolution and SNR in MR microscopy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023
    Article
  3. Enhanced spatial resolution in magnetic resonance imaging by dynamic nuclear polarization at 5 K.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eric MooreLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.
Robert TyckoLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Electronic address: robertty@mail.nih.gov.
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Development of Solid State NMR Methods and TechnologyZIADK029029 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI TYCKO, ROBERT · 2009 to 2025
$9.6M
Intramural NIH HHS ZIA DK029029
6 · The paper itself

Abstract

We describe and demonstrate a novel apparatus for magnetic resonance imaging (MRI), suitable for imaging of both liquid and solid samples with micron-scale isotropic resolution. The apparatus includes a solenoidal radio-frequency microcoil with 170 μm inner diameter and a set of planar gradient coils, all wound by hand and supported on a series of stacked sapphire plates. The design ensures efficient heat dissipation during gradient pulses and also facilitates disassembly, sample changes, and reassembly. To demonstrate liquid state (1)H MRI, we present an image of polystyrene beads within CuSO4-doped water, contained within a capillary tube with 100 μm inner diameter, with 5.0 μm isotropic resolution. To demonstrate solid state (1)H MRI, we present an image of NH4Cl particles within the capillary tube, with 8.0 μm isotropic resolution. High-resolution solid state MRI is enabled by frequency-switched Lee-Goldburg decoupling, with an effective rotating frame field amplitude of 289 kHz. At room temperature, pulsed gradients of 4 T/m (i.e., 170 Hz/μm for (1)H MRI) are achievable in all three directions with currents of 10 A or less. The apparatus is contained within a variable-temperature liquid helium cryostat, which will allow future efforts to obtain MRI images at low temperatures with signal enhancement by dynamic nuclear polarization.

Indexed as

Ammonium ChlorideCopper SulfateDiffusionEquipment DesignMagnetic Resonance ImagingMicrospheresPolystyrenesTemperatureAmmonium ChlorideCopper SulfatePolystyrenesConstant-time imagingLee–Goldburg decouplingMicrocoilMRISolid state NMR

Identifiers

PMID26397215
PMCPMC4628880
OpenAlexW1662643488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.