ArticleAmerican journal of translational research2015
Effects of sequentially released BMP-2 and BMP-7 from PELA microcapsule-based scaffolds on the bone regeneration.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Design Strategies to Target Joint Resident Mesenchymal Stem Cells for Osteochondral Regeneration.Cells · 2026Review
- Optimizing Delivery of Therapeutic Growth Factors for Bone and Cartilage Regeneration.Gels (Basel, Switzerland) · 2023Review
- A 3D-Printed Biomaterial Scaffold Reinforced with Inorganic Fillers for Bone Tissue Engineering: In Vitro Assessment and In Vivo Animal Studies.International journal of molecular sciences · 2023Article
- Sustained delivery of the bone morphogenetic proteins BMP-2 and BMP-7 for cartilage repair and regeneration in osteoarthritis.Osteoarthritis and cartilage open · 2022Article
- In vitro Evaluation of a 20% Bioglass-Containing 3D printable PLA Composite for Bone Tissue Engineering.International journal of bioprinting · 2022Article
- Development of FGF-2-loaded electrospun waterborne polyurethane fibrous membranes for bone regeneration.Regenerative biomaterials · 2021Article
- [Vascular endothelial growth factor/polylactide-polyethyleneglycol-polylactic acid copolymer/basic fibroblast growth factor mixed microcapsules in promoting angiogenic differentiation of rat bone marrow mesenchymal stem cellsZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
- Notch signaling negatively regulates BMP9-induced osteogenic differentiation of mesenchymal progenitor cells by inhibiting JunB expression.Oncotarget · 2017Article
- 3D printed TCP-based scaffold incorporating VEGF-loaded PLGA microspheres for craniofacial tissue engineering.Dental materials : official publication of the Academy of Dental Materials · 2017Article
- [FGF-2/PELA/BMP-2 microcapsule scaffold promotes osteogenic differentiation of rat periosteum-derived stem cells in vitro].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- Platelet-Rich Plasma-Loaded Poly(d,l-lactide)-Poly(ethylene glycol)-Poly(d,l-lactide) Hydrogel Dressing Promotes Full-Thickness Skin Wound Healing in a Rodent Model.International journal of molecular sciences · 2016Article
- Effects of osteoprotegerin, RANK and RANKL on bone destruction and collapse in avascular necrosis femoral head.American journal of translational research · 2016Article
- Bone Morphogenetic Protein 7 Expression in Alveolar Bone Addition With Autologous Blood, Lyophilized Bone and Atelocollagen.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoinductive biomaterials are helpful for the therapy of large bone defects and provide an alternative to autogenous bone and allografts. Recently, multiple growth factors are delivered to mimic the natural process of bone healing in the bone tissue engineering. Herein, we investigated the effects of sequential released bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-7 (BMP-7) from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on the bone regeneration. Through improving the double emulsion/solvent evaporation technique, BMP-7 was encapsulated in PELA microcapsules, to the surface of which BMP-2 was attached. Then, the scaffold (BMP-2/PELA/BMP-7) was fused by these microcapsules with dichloromethane vapor method. In vitro, it sequentially delivered bioactive BMP-2 and BMP-7 and partially imitated the profile of BMPs expression during the fracture healing. To determine the bioactivity of released BMP-2 and BMP-7, alkaline phosphatase (AKP) activity was analyzed in MC3T3-E1 cells. When compared with simple BMP-2 plus BMP-7group and pure PELA group, the AKP activity in BMP-2/PELA/BMP-7 group significantly increased. MTT assay indicated the BMP-loaded PELA scaffold had no adverse effects on cell activity. In addition, the effects of BMP-loaded scaffolds were also investigated in a rat femoral defect model by micro-computed tomographic (mCT) and histological examination. At 4 and 8 weeks post-implantation, BMP-2/PELA/BMP-7 significantly promoted osteogenesis as compared to other groups. The scaffold underwent gradual degradation and replacement by new bones at 8 weeks. Our findings suggest that the sequential release of BMP-2 and BMP-7from PELA microcapsule-based scaffolds is promising for the therapy of bone defects.
Indexed as
Identifiers
26396672PMC4568797What OpenQuestion holds
Registered trials
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