ArticleThe Journal of biological chemistry2015
Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage.Cardiovascular research · 2025Article
- Forward programming of hPSCs to neutrophils using chemically defined media.Stem cell research & therapy · 2025Article
- ETV2 transcriptionally activates Rig1 gene expression and promotes reprogramming of the endothelial lineage.Scientific reports · 2024Article
- PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension.Pulmonary circulation · 2024Article
- Transcription factors regulating vasculogenesis and angiogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Review
- ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.Cell reports · 2023Article
- SeATAC: a tool for exploring the chromatin landscape and the role of pioneer factors.Genome biology · 2023Article
- Engineered Vasculogenic Extracellular Vesicles Drive Nonviral Direct Conversions of Human Dermal Fibroblasts into Induced Endothelial Cells and Improve Wound Closure.Advanced therapeutics · 2023Article
- ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis.Frontiers in cell and developmental biology · 2023Article
- Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.Nucleic acids research · 2022Article
- Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud.Nature communications · 2022Article
- Differential Etv2 threshold requirement for endothelial and erythropoietic development.Cell reports · 2022Article
- ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage.Nature cell biology · 2022Article
- Transcription Regulation ofBiology · 2022Article
- The regulatory role of pioneer factors during cardiovascular lineage specification - A mini review.Frontiers in cardiovascular medicine · 2022Review
- Blastocyst complementation and interspecies chimeras in gene edited pigs.Frontiers in cell and developmental biology · 2022Review
- Interspecies chimeras as a platform for exogenic organ production and transplantation.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- ETV2-null porcine embryos survive to post-implantation following incomplete enucleation.Reproduction (Cambridge, England) · 2020Article
- Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics.Stem cell reports · 2020Review
- Generation of human endothelium in pig embryos deficient in ETV2.Nature biotechnology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Etv2 is an essential transcriptional regulator of hematoendothelial lineages during embryogenesis. Although Etv2 downstream targets have been identified, little is known regarding the upstream transcriptional regulation of Etv2 gene expression. In this study, we established a novel methodology that utilizes the differentiating ES cell and embryoid body system to define the modules and enhancers embedded within the Etv2 promoter. Using this system, we defined an autoactivating role for Etv2 that is mediated by two adjacent Ets motifs in the proximal promoter. In addition, we defined the role of VEGF/Flk1-Calcineurin-NFAT signaling cascade in the transcriptional regulation of Etv2. Furthermore, we defined an Etv2-Flt1-Flk1 cascade that serves as a negative feedback mechanism to regulate Etv2 gene expression. To complement and extend these studies, we demonstrated that the Flt1 null embryonic phenotype was partially rescued in the Etv2 conditional knockout background. In summary, these studies define upstream and downstream networks that serve as a transcriptional rheostat to regulate Etv2 gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.