SynthesisAllergy2016
Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies.
Synthesis in Allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review.Developmental psychobiology · 2026Pooled it
- The Association between Maternal Stress and Childhood Eczema: A Systematic Review.International journal of environmental research and public health · 2018Pooled it
- Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies.Allergy · 2016Pooled it
- Perinatal Risk Factors, Allergic Conditions and Psychosocial Problems in Children and Adolescents with Mental Health Problems.Research on child and adolescent psychopathology · 2026Article
- Prenatal depression and psychotropics in offspring asthma and atopic dermatitis.Journal of the Chinese Medical Association : JCMA · 2026Article
- Comorbidity of asthma and attention deficit hyperactivity disorder in childhood: causal, shared early-life risk factors, or shared genetic liability?International journal of epidemiology · 2026Article
- Article
- Early-Life Environmental Determinants of Allergic Conditions in Children with Atopic Heredity: A Single Center Cross-Sectional Study from Bulgaria.Medical sciences (Basel, Switzerland) · 2025Article
- Proposed Physiological Mechanisms Underlying the Association between Adverse Childhood Experiences and Mental Health Conditions: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Maternal stressful life events during pregnancy and childhood asthma and wheeze.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Factors of Fetal Origin in the Regulation of Labor Initiation and Preterm Birth.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Atopic Dermatitis Across Shades of Skin.American journal of clinical dermatology · 2023Review
- Obsessive compulsive symptoms in mothers of children with atopic dermatitis.Postepy dermatologii i alergologii · 2023Article
- Risk Assessment of Allergic Diseases Among Preschool Children in Guangzhou, China: A Cross-Sectional Study.Journal of asthma and allergy · 2023Article
- Mothers' Sexual Identity and Children's Health.Population research and policy review · 2022Article
- Article
- Maternal prenatal psychological distress associates with offspring early-life wheezing - FinnBrain Birth Cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Associations Between Maternal Distress During Early Life Periods and Offspring Respiratory Infections and Allergic Outcomes.Frontiers in pediatrics · 2022Article
- Environmental exposure during pregnancy and the risk of childhood allergic diseases.World journal of pediatrics : WJP · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA growing number of studies suggest that maternal stress during pregnancy promotes atopic disorders in the offspring. This is the first systematic review to address prenatal maternal stress (PNMS) and the subsequent risk of atopy-related outcomes in the child.
methodsThe review was performed in accordance to the PRISMA criteria. We searched and selected studies in PubMed, Scopus, Embase and PsychINFO until November 2014.
resultsSixteen (with 25 analyses) of 426 identified articles met the review criteria. Five main PNMS exposures (negative life events, anxiety/depression, bereavement, distress and job strain) and five main atopic outcomes (asthma, wheeze, atopic dermatitis, allergic rhinitis and IgE) were assessed across the studies. Overall, 21 of the 25 analyses suggested a positive association between PNMS and atopic outcomes. Of the 11 exposure-response analyses reported, six found statistically significant trends.
conclusionThis systematic review suggests a relationship between maternal stress during pregnancy and atopic disorders in the child. However, the existing studies are of diverse quality. The wide definitions of often self-reported stress exposures imply a substantial risk for information bias and false-positive results. Research comparing objective and subjective measures of PNMS exposure as well as objective measures for atopic outcome is needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.