ArticleScientific reports2015
A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1-BARD1 complex.The Journal of biological chemistry · 2026Article
- Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.iScience · 2023Article
- Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.Cell genomics · 2023Article
- Preparation of Tunable Microchips to Visualize Native Protein Complexes for Single-Particle Electron Microscopy.Methods in molecular biology (Clifton, N.J.) · 2018Article
- A Multiscale Computational Model for Simulating the Kinetics of Protein Complex Assembly.Methods in molecular biology (Clifton, N.J.) · 2018Article
- RETRACTED: Structural analysis of BRCA1 reveals modification hotspot.Science advances · 2017Article
- Tunable substrates improve imaging of viruses and cancer proteins.Microscopy today · 2017Article
- Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.Scientific reports · 2017Article
- Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy.Methods in molecular biology (Clifton, N.J.) · 2017Article
- A microchip platform for structural oncology applications.NPJ breast cancerArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select for target proteins of interest and analyze them using molecular microscopy. Implementing our new streamlined microchip approach, we could directly visualize BRCA1 gene regulatory complexes from patient-derived cancer cells for the first time.
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Registered trials
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