Evidence map›Paper›PMID 26395816›Full record

ArticleThe Journal of allergy and clinical immunology2016

GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis.

Michael A Spinner, Jennifer P Ker, Charles J Stoudenmire, Oluwole Fadare, Emily M Mace, Jordan S Orange, Amy P Hsu, Steven M Holland

Abstract readCase Reports
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  4. Human immunity to fungal infections.The Journal of experimental medicine · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (Non-EBV).Advances in experimental medicine and biology · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Histiocytic disorders.Nature reviews. Disease primers · 2021
    Review
  19. Clinical Manifestations and Outcomes in Immunocompetent and Immunocompromised Patients With Blastomycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael A SpinnerDepartment of Medicine, Stanford University Medical Center, Stanford, Calif.
Jennifer P KerDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Charles J StoudenmireDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn.
Oluwole FadareDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tenn.
Emily M MaceCenter for Human Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex.
Jordan S OrangeCenter for Human Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex.
Amy P HsuLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: smh@nih.gov.

Funding

Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
GENES AND GENE PRODUCTS AS IMMUNOADJUVANTSZ01AI000647 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$5.4M
TRANSGENIC ANIMAL MODELS OF HUMAN IMMUNE DEFECTSZ01AI000646 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$2.4M
Intramural NIH HHS Z01 AI000646NIAID NIH HHS Z01-AI-00647-25
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

SimplexvirusAdolescentBlastomycosisFatal OutcomeFemaleGATA2 Transcription FactorHerpes SimplexHumansLymphohistiocytosis, HemophagocyticGATA2 Transcription Factor

Identifiers

PMID26395816
PMCPMC4747814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.