ArticleInternational journal of obesity (2005)2016
Adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Insights into intramuscular adipose-muscle signaling in the diabetic lower extremity.Journal of clinical & translational endocrinology · 2025Article
- Intramuscular adipose tissue: from progenitor to pathology.American journal of physiology. Cell physiology · 2025Review
- CircGLIS3 Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration.Journal of cachexia, sarcopenia and muscle · 2025Article
- Review
- Relationship Between Triglyceride-Glucose Index and Handgrip Strength in the Midlife and Elderly Population: Evidence From a Chinese Cohort.International journal of endocrinology · 2025Article
- Optimal fasting duration for mice as assessed by metabolic status.Scientific reports · 2024Article
- The association between the triglyceride-glucose index and sarcopenia: data from the NHANES 2011-2018.Lipids in health and disease · 2024Article
- Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.Molecular aspects of medicine · 2024Review
- Development and expansion of intramuscular adipose tissue is not dependent on UCP-1-lineage cells in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury.Nature communications · 2023Article
- Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms.Frontiers in endocrinology · 2023Review
- Magnetic Resonance Imaging Assessment of Abdominal Ectopic Fat Deposition in Correlation With Cardiometabolic Risk Factors.Frontiers in endocrinology · 2022Article
- Single-cell RNA sequencing and lipidomics reveal cell and lipid dynamics of fat infiltration in skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2021Article
- The Impact of Dysmetabolic Sarcopenia Among Insulin Sensitive Tissues: A Narrative Review.Frontiers in endocrinology · 2021Review
- Reappraisal of the optimal fasting time for insulin tolerance tests in mice.Molecular metabolism · 2020Article
- Brown Fat Promotes Muscle Growth During Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans.American journal of physiology. Endocrinology and metabolism · 2019Article
- Intramuscular adipocytes: a buried adipose tissue depot deserving more exploration.Journal of lipid research · 2019Article
- The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function.Stem cell research & therapy · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesRecent reports indicate that inter/intramuscular adipose tissue (IMAT), composed by adipocytes underneath the deep fascia of the muscles, is positively correlated with aging, obesity and insulin resistance in humans. However, no molecular/cellular evidence is available to support these interactions. The current study aimed to better characterize human skeletal muscle-derived adipogenic progenitors obtained from obese volunteers and investigate the impact of derived adipocytes on insulin action in primary skeletal muscle cells.
methodsPrimary cultured stroma-vascular fraction (SVF) obtained from vastus lateralis muscle biopsies of middle-aged obese subjects was immunoseparated (magnetic beads or flow cytometry). The characteristics and/or metabolic phenotype of CD56(+), CD56(-) and CD56(-)CD15(+) cellular fractions were investigated by complementary approaches (flow cytometry, cytology, quantitative PCR and metabolic assays). The effects of conditioned media from CD56(-)CD15(+) cells differentiated into adipocytes on insulin action and signaling in human primary myotubes was also examined.
resultsOur data indicate that CD56(+) and CD56(-) cellular fractions isolated from cultured SVF of human muscle contain two distinct committed progenitors: CD56(+) cells (that is, satellite cells) as myogenic progenitors and CD15(+) cells as adipogenic progenitors, respectively. CD56(-)CD15(+)-derived adipocytes display the phenotype and metabolic properties of white adipocytes. Secretions of CD56(-)CD15(+) cells differentiated into functional white adipocytes reduced insulin-mediated non-oxidative glucose disposal (P=0.0002) and insulin signaling.
conclusionsUsing in-vitro models, we show for the first time that secretions of skeletal muscle adipocytes are able to impair insulin action and signaling of muscle fibers. This paracrine effect could explain, at least in part, the negative association between high levels of IMAT and insulin sensitivity in obesity and aging.
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