Evidence map›Paper›PMID 26395640›Full record

ReviewHuman reproduction update

Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome.

Silvia Vannuccini, Vicki L Clifton, Ian S Fraser, Hugh S Taylor, Hilary Critchley, Linda C Giudice, Felice Petraglia

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 10 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 10 syntheses or guidelines pooled it, 368 citations in OpenAlex.

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114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Silvia VannucciniDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecology, University of Siena, Siena, Italy.
Vicki L CliftonRobinson Research Institute, University of Adelaide, Adelaide, Australia.
Ian S FraserDepartment of Obstetrics and Gynaecology, Center for Women's Health, University of New South Wales, Sydney, Australia.
Hugh S TaylorDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA.
Hilary CritchleyMRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Linda C GiudiceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California, 550 16th Street, Floor 7, Box 0132, San Francisco, CA 94143, USA linda.giudice@ucsf.edu.
Felice PetragliaDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecology, University of Siena, Siena, Italy.
University of Siena · ITMRC Centre for Reproductive Health · GBUniversity of Adelaide · AUUniversity of California, San Francisco · USUNSW Sydney · AUYale University · US

Funding

Project 4: Human Endometrial Programming for Successful ImplantationP50HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIUDICE, LINDA C · 2014 to 2022
$16.4M
Medical Research Council MR/J003611/1NICHD NIH HHS P50 HD055764
6 · The paper itself

Abstract

backgroundReproductive disorders and infertility are associated with the risk of obstetric complications and have a negative impact on pregnancy outcome. Affected patients often require assisted reproductive technologies (ART) to conceive, and advanced maternal age is a further confounding factor. The challenge is to dissect causation, correlation and confounders in determining how infertility and reproductive disorders individually or together predispose women to poor pregnancy outcomes.

methodsThe published literature, to June 2015, was searched using PubMed, summarizing all evidences concerning the perinatal outcome of women with infertility and reproductive disorders and the potential mechanisms that may influence poor pregnancy outcome.

resultsReproductive disorders (endometriosis, adenomyosis, polycystic ovary syndrome and uterine fibroids) and unexplained infertility share inflammatory pathways, hormonal aberrations, decidual senescence and vascular abnormalities that may impair pregnancy success through common mechanisms. Either in combination or alone, these disorders results in an increased risk of preterm birth, fetal growth restriction, placental pathologies and hypertensive disorders. Systemic hormonal aberrations, and inflammatory and metabolic factors acting on endometrium, myometrium, cervix and placenta are all associated with an aberrant milieu during implantation and pregnancy, thus contributing to the genesis of obstetric complications. Some of these features have been also described in placentas from ART.

conclusionsReproductive disorders are common in women of childbearing age and rarely occur in isolation. Inflammatory, endocrine and metabolic mechanisms associated with these disorders are responsible for an increased incidence of obstetric complications. These patients should be recognized as 'high risk' for poor pregnancy outcomes and monitored with specialized follow-up. There is a real need for development of evidence-based recommendations about clinical management and specific obstetric care pathways for the introduction of prompt preventative care measures.

Indexed as

Cervix UteriFemaleFemale Urogenital DiseasesGonadal Steroid HormonesHumansInfertility, FemaleInflammationLeiomyomaMaternal AgePlacentaPolycystic Ovary SyndromePregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthReproductive Techniques, AssistedGonadal Steroid Hormonesassisted reproductive technologiesendometriosisinflammationplacentapolycystic ovary syndromepre-eclampsiapreterm birthsex steroidsunexplained infertilityuterine fibroids

Identifiers

PMID26395640
PMCPMC7289323
OpenAlexW1947692703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.