ReviewPhysiological genomics2016
Rodent models for resolving extremes of exercise and health.
Review in Physiological genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Exercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements.Diabetes, obesity & metabolism · 2026Article
- The effects of short-term consumption of a Western diet on aerobic exercise performance in bank voles with inherently distinct metabolic rates.Experimental physiology · 2026Article
- Tumor Signatures of Physical Fitness: Insights from a Preclinical Model.Medicine and science in sports and exercise · 2026Article
- FLEX: Flight Exercise Training Protocol for the Fruit Fly Drosophila.Journal of visualized experiments : JoVE · 2025Article
- Aerobic capacity and muscle proteome: Insights from a mouse model.Experimental physiology · 2025Article
- The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism.Frontiers in physiology · 2022Review
- Multiple Applications of Different Exercise Modalities with Rodents.Oxidative medicine and cellular longevity · 2021Review
- Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases.Physiological genomics · 2020Article
- Genes Whose Gain or Loss-of-Function Increases Endurance Performance in Mice: A Systematic Literature Review.Frontiers in physiology · 2019Review
- Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.Reproduction (Cambridge, England) · 2018Article
- The role of DNA-PK in aging and energy metabolism.The FEBS journal · 2018Review
- Are There Limitations to Exercise Benefits in Peripheral Arterial Disease?Frontiers in cardiovascular medicine · 2018Review
- DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.Cell metabolism · 2017Article
- Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet.Physiological reports · 2017Article
- Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome.Frontiers in immunology · 2017Article
- "Weighing" the effects of exercise and intrinsic aerobic capacity: are there beneficial effects independent of changes in weight?Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The extremes of exercise capacity and health are considered a complex interplay between genes and the environment. In general, the study of animal models has proven critical for deep mechanistic exploration that provides guidance for focused and hypothesis-driven discovery in humans. Hypotheses underlying molecular mechanisms of disease and gene/tissue function can be tested in rodents to generate sufficient evidence to resolve and progress our understanding of human biology. Here we provide examples of three alternative uses of rodent models that have been applied successfully to advance knowledge that bridges our understanding of the connection between exercise capacity and health status. First we review the strong association between exercise capacity and all-cause morbidity and mortality in humans through artificial selection on low and high exercise performance in the rat and the consequent generation of the "energy transfer hypothesis." Second we review specific transgenic and knockout mouse models that replicate the human disease condition and performance. This includes human glycogen storage diseases (McArdle and Pompe) and α-actinin-3 deficiency. Together these rodent models provide an overview of the advancements of molecular knowledge required for clinical translation. Continued study of these models in conjunction with human association studies will be critical to resolving the complex gene-environment interplay linking exercise capacity, health, and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.