ArticleEuropean journal of human genetics : EJHG2016
A minimum set of ancestry informative markers for determining admixture proportions in a mixed American population: the Brazilian set.
Article in European journal of human genetics : EJHG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Developing a germline prostate cancer risk test incorporating rare and common variants, to inform clinical decisions: a route to precision oncology.Genome medicine · 2026Article
- Peripheral Expression of Dopamine Genes as a Biomarker for Cocaine Addiction in Humans.European addiction research · 2026Article
- The Role of Dermocosmetics in Acne Management: Implications for Clinical Practice in Brazil.Clinical, cosmetic and investigational dermatology · 2026Review
- Screening for Mutations in Hereditary Cancer Susceptibility Genes in a Region with High Endogamy in Brazil.Global medical genetics · 2023Article
- Spirometry in Mixed-Race Civil War Veterans.Annals of the American Thoracic Society · 2023Article
- Unsupervised discovery of ancestry-informative markers and genetic admixture proportions in biobank-scale datasets.American journal of human genetics · 2023Article
- Challenges in selecting admixture models and marker sets to infer genetic ancestry in a Brazilian admixed population.Scientific reports · 2022Article
- Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.PLoS neglected tropical diseases · 2022Article
- Demographic history differences between Hispanics and Brazilians imprint haplotype features.G3 (Bethesda, Md.) · 2022Article
- Genetic ancestry plays a central role in population pharmacogenomics.Communications biology · 2021Article
- Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.BMC cancer · 2020Article
- Genetic Consequences of the Transatlantic Slave Trade in the Americas.American journal of human genetics · 2020Article
- Evaluation of the Precision of Ancestry Inferences in South American Admixed Populations.Frontiers in genetics · 2020Article
- Ancestry informative markers (AIMs) for Korean and other East Asian and South East Asian populations.International journal of legal medicine · 2019Article
- Genetic comparison of sickle cell anaemia cohorts from Brazil and the United States reveals high levels of divergence.Scientific reports · 2019Article
- Context-dependence of race self-classification: Results from a highly mixed and unequal middle-income country.PloS one · 2019Article
- Selection of Optimal Ancestry Informative Markers for Classification and Ancestry Proportion Estimation in Pigs.Frontiers in genetics · 2019Article
- An Ancestry Informative Marker Set Which Recapitulates the Known Fine Structure of Populations in South Asia.Genome biology and evolution · 2018Article
- High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.Immunogenetics · 2018Article
- Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing.PloS one · 2018Article
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Authors and funding
17 authors.
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Abstract
The Brazilian population is considered to be highly admixed. The main contributing ancestral populations were European and African, with Amerindians contributing to a lesser extent. The aims of this study were to provide a resource for determining and quantifying individual continental ancestry using the smallest number of SNPs possible, thus allowing for a cost- and time-efficient strategy for genomic ancestry determination. We identified and validated a minimum set of 192 ancestry informative markers (AIMs) for the genetic ancestry determination of Brazilian populations. These markers were selected on the basis of their distribution throughout the human genome, and their capacity of being genotyped on widely available commercial platforms. We analyzed genotyping data from 6487 individuals belonging to three Brazilian cohorts. Estimates of individual admixture using this 192 AIM panels were highly correlated with estimates using ~370 000 genome-wide SNPs: 91%, 92%, and 74% of, respectively, African, European, and Native American ancestry components. Besides that, 192 AIMs are well distributed among populations from these ancestral continents, allowing greater freedom in future studies with this panel regarding the choice of reference populations. We also observed that genetic ancestry inferred by AIMs provides similar association results to the one obtained using ancestry inferred by genomic data (370 K SNPs) in a simple regression model with rs1426654, related to skin pigmentation, genotypes as dependent variable. In conclusion, these markers can be used to identify and accurately quantify ancestry of Latin Americans or US Hispanics/Latino individuals, in particular in the context of fine-mapping strategies that require the quantification of continental ancestry in thousands of individuals.
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