ArticleDevelopment (Cambridge, England)2015
Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026Review
- Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development.Communications biology · 2026Article
- The Proteome ofProteomes · 2026Article
- Dictyostelium discoideum chemotaxis is altered by hypoxia to orient streaming toward higher oxygen levels.BMC molecular and cell biology · 2025Article
- Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development.BMC genomics · 2025Article
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- New insights into the N-glycomes ofBBA advances · 2025Article
- The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.Nature communications · 2024Article
- Parallel evolution of the G protein-coupled receptor GrlG and the loss of fruiting body formation in the social amoeba Dictyostelium discoideum evolved under low relatedness.G3 (Bethesda, Md.) · 2023Article
- Transcriptional milestones inGenome research · 2021Article
- Cyclic AMP is dispensable for allorecognition in Dictyostelium cells overexpressing PKA-C.Journal of cell science · 2021Article
- Polar pattern formation induced by contact following locomotion in a multicellular system.eLife · 2020Article
- Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.eLife · 2020Article
- WildEcology and evolution · 2020Article
- DPF is a cell-density sensing factor, with cell-autonomous and non-autonomous functions during Dictyostelium growth and development.BMC biology · 2019Article
- Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Discrimination Experiments in Entamoeba and Evidence from Other Protists Suggest Pathogenic Amebas Cooperate with Kin to Colonize Hosts and Deter Rivals.The Journal of eukaryotic microbiology · 2019Review
- Oscillatory cAMP cell-cell signalling persists during multicellularCommunications biology · 2019Article
- Cellular allorecognition and its roles in Dictyostelium development and social evolution.The International journal of developmental biology · 2019Review
- Collective cell migration ofCommunications biology · 2019Article
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5 authors.
Funding
Abstract
The social amoeba Dictyostelium discoideum integrates into a multicellular organism when individual starving cells aggregate and form a mound. The cells then integrate into defined tissues and develop into a fruiting body that consists of a stalk and spores. Aggregation is initially orchestrated by waves of extracellular cyclic adenosine monophosphate (cAMP), and previous theory suggested that cAMP and other field-wide diffusible signals mediate tissue integration and terminal differentiation as well. Cooperation between cells depends on an allorecognition system comprising the polymorphic adhesion proteins TgrB1 and TgrC1. Binding between compatible TgrB1 and TgrC1 variants ensures that non-matching cells segregate into distinct aggregates prior to terminal development. Here, we have embedded a small number of cells with incompatible allotypes within fields of developing cells with compatible allotypes. We found that compatibility of the allotype encoded by the tgrB1 and tgrC1 genes is required for tissue integration, as manifested in cell polarization, coordinated movement and differentiation into prestalk and prespore cells. Our results show that the molecules that mediate allorecognition in D. discoideum also control the integration of individual cells into a unified developing organism, and this acts as a gating step for multicellularity.
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