Trial reportClinical oral investigations2016
Prevention in kindergartens with 500 ppm fluoride toothpaste-a randomized clinical trial.
Trial report in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05512156 (Toothbrushing Program in Saudi Arabia "TOPS"- A Cluster Randomized Controlled Trial in Kindergartens, Riyadh), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Toothbrushing Program in Saudi Arabia "TOPS"- A Cluster Randomized Controlled Trial in Kindergartens, Riyadh
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Supervised toothbrushing programs: evaluating impact, barriers, and facilitators - a mixed-method umbrella review.Evidence-based dentistry · 2025Pooled it
- The effectiveness of school-based supervised tooth brushing intervention for preventing dental caries: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Long-term effect of intensive prevention on dental health of primary school children by socioeconomic status.Clinical oral investigations · 2018Trial
- Successful Oral Health Interventions for Children Living in Vulnerable Circumstances - A Scoping Review.International dental journal · 2025Article
- Observational
- Caries Experience and Increment in Children Attending Kindergartens with an Early Childhood Caries Preventive Program Compared to Basic Prophylaxis Measures-A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Effect of supervised brushing with fluoride gel during primary school, taking into account the group prevention schedule in kindergarten.Clinical oral investigations · 2017Observational
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of the study was to evaluate the effect of an intensified preventive programme in kindergartens. MATERIALS AND
methodsTwo thousand two hundred twenty-eight 2- to 4-year-old children attending kindergartens in two counties in northern Hesse were randomly allocated to two groups. Children in the test group participated in daily tooth brushing with 500 ppm fluoride toothpaste, which was supervised by specially trained dental nurses. Children in the control group received tooth brushing instructions three to four times a year. Caries experience was recorded using WHO criteria. The basic survey was performed from October 2006 to April 2007, with the final examinations between March and July 2009. The statistical evaluation was performed by means of the software package SPSS 17.0. To compare the mean Δdmf values of the test and control groups, Mann-Whitney U tests were performed.
resultsTwo thousand one hundred twelve children (test group, 1096; control group, 1048) participated in the final examinations. The caries increment of the test group (Δdmf-s = 1.55) was 24 % lower than the increment of the control group (Δdmf-s = 2.02, p = 0.043). Based on Δdmf-t values, the corresponding figures were 0.79 for the test group and 1 for the control group (p = 0.44). High increment values (Δdmf-s >7) were observed in the control group twice as often as in the test group.
conclusionThe results show that an intensified preventive programme in kindergartens, based on supervised daily tooth brushing, has a positive effect on the dental health of preschool children. CLINICAL RELEVANCE: It is sufficient to offer such programmes in socially deprived areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.