ReviewCritical care (London, England)2015
Postextubation laryngeal edema and stridor resulting in respiratory failure in critically ill adult patients: updated review.
Review in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06203405 (The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Liberation from mechanical ventilation in critically ill patients: Korean Society of Critical Care Medicine Clinical Practice Guidelines.Acute and critical care · 2024Guideline
- Diagnostic efficacy of sonographic measurement of laryngeal air column width difference for predicting the risk of post-extubation stridor: A meta-analysis of observational studies.Frontiers in medicine · 2023Pooled it
- Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- [Influence of methylprednisolone on the reversal time of sugammadex: a randomized clinical trial].Brazilian journal of anesthesiology (Elsevier)Trial
- Article
- Article
- Association of Prophylactic Corticosteroids with Post-Extubation Outcomes in Pediatric Cardiac Critical Care: A Retrospective Propensity-Weighted Cohort Study.Journal of clinical medicine · 2026Article
- Identifying the association between post-extubation laryngeal edema and aspiration in acute respiratory failure patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Observational
- Delayed-Onset and Prolonged Laryngeal Edema Following Pyrethroid Insecticide Poisoning: A Case Report.Cureus · 2026Article
- Evaluation of Vocal Cord Paralysis Following Lung Transplantation.Laryngoscope investigative otolaryngology · 2026Article
- All India Difficult Airway Association 2025 guidelines for extubation of the "at-risk" airway.Indian journal of anaesthesia · 2025Article
- Bridging the Gap: The Role of Non-Invasive Respiratory Supports in Weaning from Invasive Mechanical Ventilation.Journal of clinical medicine · 2025Review
- Preoxygenation in the ICU.Journal of clinical medicine · 2025Review
- Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.Critical care (London, England) · 2025Observational
- Severe laryngeal oedema unexpectedly observed during bronchoscopy in a patient with anti-MDA5-positive dermatomyositis.BMJ case reports · 2025Article
- Delayed Onset of Post-Intubation Laryngeal Oedema: Navigating Patient Autonomy and Successful Medical Management.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Predictive factors in difficult postoperative airway management of severe odontogenic deep neck infection.Odontology · 2025Article
- Airway Ultrasound: A Narrative Review of Present Use and Future Applications in Anesthesia.Healthcare (Basel, Switzerland) · 2025Review
- Challenge of tracheal extubation and tube exchange of a difficult airway: a narrative review.Journal of anesthesia · 2025Review
- Increased cuff-leak pressure after abdominal and spine surgeries: a simple and novel cuff-leak test for tracheal extubation.Journal of anesthesia · 2025Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endotracheal intubation is frequently complicated by laryngeal edema, which may present as postextubation stridor or respiratory difficulty or both. Ultimately, postextubation laryngeal edema may result in respiratory failure with subsequent reintubation. Risk factors for postextubation laryngeal edema include female gender, large tube size, and prolonged intubation. Although patients at low risk for postextubation respiratory insufficiency due to laryngeal edema can be identified by the cuff leak test or laryngeal ultrasound, no reliable test for the identification of high-risk patients is currently available. If applied in a timely manner, intravenous or nebulized corticosteroids can prevent postextubation laryngeal edema; however, the inability to identify high-risk patients prevents the targeted pretreatment of these patients. Therefore, the decision to start corticosteroids should be made on an individual basis and on the basis of the outcome of the cuff leak test and additional risk factors. The preferential treatment of postextubation laryngeal edema consists of intravenous or nebulized corticosteroids combined with nebulized epinephrine, although no data on the optimal treatment algorithm are available. In the presence of respiratory failure, reintubation should be performed without delay. Application of noninvasive ventilation or inhalation of a helium/oxygen mixture is not indicated since it does not improve outcome and increases the delay to intubation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.