ArticleThe Journal of dermatological treatment2016
Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale.
Article in The Journal of dermatological treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- An integrative pharmacovigilance, network toxicology and molecular docking study on drug-induced cheilitis.Frontiers in pharmacology · 2026Article
- Real-World Safety of Oral Isotretinoin in Patients During Sunny Months: Retrospective Cohort Study.Dermatology practical & conceptual · 2025Article
- Image based quantification method reveals differential patterns of lip desquamation associated with age and sex.Scientific reports · 2025Article
- Survey Defining Lip Health-Dermatology and Health Care Providers' Perspectives.Journal of cosmetic dermatology · 2025Article
- Isotretinoin-unresponsive acne as a sign of a congenital disorder: a case of 21-hydroxylase deficiency.Dermatology reports · 2024Article
- Prospective Placebo-Controlled Assessment of Spore-Based Probiotic Supplementation on Sebum Production, Skin Barrier Function, and Acne.Journal of clinical medicine · 2023Article
- Lip Mesotherapy with Dexpanthenol as a Novel Approach to Prevent Isotretinoin-Associated Cheilitis.Dermatology practical & conceptual · 2023Article
- Creatine Phosphokinase Values during Low Starting Dose Isotretinoin Therapy.Skin appendage disorders · 2020Article
- Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience.Clinical, cosmetic and investigational dermatology · 2019Article
- Drug repurposing of dermatologic medications to treat coronavirus disease 2019: Science or fiction?Clinics in dermatologyArticle
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Authors and funding
7 authors.
Funding
Abstract
importanceIsotretinoin remains an effective treatment for severe acne. Despite its effectiveness, it includes many side effects, of which cheilitis is the most common.
objectiveTo develop an objective grading scale for assessment of isotretinoin-associated cheilitis.
designCross-sectional clinical grading study.
settingUC Davis Dermatology clinic.
participantsSubjects were older than 18 years old and actively treated with oral isotretinoin. EXPOSURES: Oral Isotretinoin. MAIN OUTCOMES AND MEASURES: We developed an Isotretinoin Cheilitis Grading Scale (ICGS) incorporating the following four characteristics: erythema, scale/crust, fissures and inflammation of the commissures. Three board-certified dermatologists independently graded photographs of the subjects.
resultsThe Kendall's coefficient of concordance (KCC) for the ICGS was 0.88 (p < 0.0001). The Kendall's coefficient was ≥0.72 (p < 0.0001) for each of the four characteristics included in the grading scale. An image-based measurement for lip roughness statistically significantly correlated with the lip scale/crusting assessment (r = 0.52, p < 0.05). CONCLUSION AND RELEVANCE: The ICGS is reproducible and relatively simple to use. It can be incorporated as an objective tool to aid in the assessment of isotretinoin associated cheilitis.
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