Evidence map›Paper›PMID 26394904›Full record

ReviewJournal of lipid research2016

GPI-anchored protein organization and dynamics at the cell surface.

Suvrajit Saha, Anupama Ambika Anilkumar, Satyajit Mayor

Abstract readReview
In one paragraph

Review in Journal of lipid research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Endocrine regulation of uromodulin in aging.Frontiers in endocrinology · 2026
    Review
  7. Observational
  8. mRNA-LNP vaccine encoding theMolecular therapy. Nucleic acids · 2025
    Article
  9. Article
  10. Sterols in plant biologyCell surface (Amsterdam, Netherlands) · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suvrajit SahaNational Centre for Biological Sciences (Tata Institute of Fundamental Research), Bangalore 560065, India.
Anupama Ambika AnilkumarNational Centre for Biological Sciences (Tata Institute of Fundamental Research), Bangalore 560065, India Shanmugha Arts, Science, Technology and Research Academy, Thanjavur 613401, India.
Satyajit MayorNational Centre for Biological Sciences (Tata Institute of Fundamental Research), Bangalore 560065, India Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore 560065, India mayor@ncbs.res.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The surface of eukaryotic cells is a multi-component fluid bilayer in which glycosylphosphatidylinositol (GPI)-anchored proteins are an abundant constituent. In this review, we discuss the complex nature of the organization and dynamics of GPI-anchored proteins at multiple spatial and temporal scales. Different biophysical techniques have been utilized for understanding this organization, including fluorescence correlation spectroscopy, fluorescence recovery after photobleaching, single particle tracking, and a number of super resolution methods. Major insights into the organization and dynamics have also come from exploring the short-range interactions of GPI-anchored proteins by fluorescence (or Förster) resonance energy transfer microscopy. Based on the nanometer to micron scale organization, at the microsecond to the second time scale dynamics, a picture of the membrane bilayer emerges where the lipid bilayer appears inextricably intertwined with the underlying dynamic cytoskeleton. These observations have prompted a revision of the current models of plasma membrane organization, and suggest an active actin-membrane composite.

Indexed as

ActinsCell MembraneFluorescence Resonance Energy TransferGlycosylphosphatidylinositolsLipid BilayersMembrane MicrodomainsMembrane ProteinsSpectrometry, FluorescenceActinsGlycosylphosphatidylinositolsLipid BilayersMembrane Proteinsactivityactomyosindiffusionglycosylphosphatidylinositol-anchored proteinhomo-fluorescence resonance energy transferlipid raftsmicrodomainsnanoscalesignal transductionsuper-resolution

Identifiers

PMID26394904
PMCPMC4727430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.