ArticleJournal of the American Chemical Society2015
Highly Selective Synthesis of Halomon, Plocamenone, and Isoplocamenone.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Eschenmoser's salts: from design to applications in organic synthesis.Organic chemistry frontiers : an international journal of organic chemistry · 2026Review
- Synthesis and applications of alkenyl chlorides (vinyl chlorides): a review.Beilstein journal of organic chemistry · 2026Review
- Synthesis and Conformational Analysis of Pyran Interhalide Analogues of Galactose, Mannose, Talose, and Glucose.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Empirical Chiroptical Analyses of Vicinal Bromochloro Natural Products by van't Hoff's Principle of Optical Superposition: Assignment of the C-16 Configurations of Callophycols A and B.The Journal of organic chemistry · 2024Article
- Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases.ACS chemical biology · 2024Article
- Synthesis and conformational analysis of pyran inter-halide analogues of ᴅ-talose.Beilstein journal of organic chemistry · 2024Article
- DeepSA: a deep-learning driven predictor of compound synthesis accessibility.Journal of cheminformatics · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Catalytic Chemo-, Regio-, Diastereo-, and Enantioselective Bromochlorination of Unsaturated Systems Enabled by Lewis Base-Controlled Chloride Release.Journal of the American Chemical Society · 2022Article
- The Electrochemical cis-Chlorination of Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Pd-catalyzed formal Mizoroki-Heck coupling of unactivated alkyl chlorides.Nature communications · 2021Article
- Cross-Electrophile Coupling of Unactivated Alkyl Chlorides.Journal of the American Chemical Society · 2020Article
- Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials.Marine drugs · 2019Review
- A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells.Marine drugs · 2019Article
- Enantioselective Synthesis of Azamerone.Journal of the American Chemical Society · 2019Article
- Total Enzyme Syntheses of Napyradiomycins A1 and B1.Journal of the American Chemical Society · 2018Article
- Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols.Journal of the American Chemical Society · 2018Article
- Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity.Marine drugs · 2018Review
- Catalytic Enantioselective Dihalogenation in Total Synthesis.Accounts of chemical research · 2018Review
- Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling.Journal of the American Chemical Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Over 160 chiral vicinal bromochlorinated natural products have been identified; however, a lack of synthetic methods for the selective incorporation of halogens into organic molecules has hindered their synthesis. Here we disclose the first total synthesis and structural confirmation of isoplocamenone and plocamenone, as well as the first selective and scalable synthesis of the preclinical anticancer natural product halomon. The synthesis of these inter-halogenated compounds has been enabled by our recently developed chemo-, regio-, and enantioselective dihalogenation reaction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.