ArticleScientific reports2015
Nanoparticles modulate autophagic effect in a dispersity-dependent manner.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Autophagy in cancer nanomedicine: an implication of nanomaterials' impact on the evolutionarily conservative catabolic processes in human tumors.Archives of toxicology · 2026Review
- Nanotherapies based on bacterial metabolism: Mechanisms, design and application.Materials today. Bio · 2025Review
- Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy.Small science · 2025Article
- Natural Compounds and their Nano-formulations in Combating Autophagy-mediated Drug Resistance in Human Cancers.Current topics in medicinal chemistry · 2025Review
- Size-dependent gold nanoparticles induce macrophage M2 polarization and promote intracellular clearance ofMaterials today. Bio · 2023Article
- Development and Characterization of Pickering Emulsion Stabilized by Walnut Protein Isolate Nanoparticles.Molecules (Basel, Switzerland) · 2023Article
- Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective.Cell & bioscience · 2023Review
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- Effect of dopamine-functionalization, charge and pH on protein corona formation around TiONanoscale · 2022Article
- Nanozyme for tumor therapy: Surface modification matters.Exploration (Beijing, China) · 2021Review
- Article
- A Simple Route to the Complexation of Lutein with Reduced Graphene Oxide Nanocarriers and Antioxidant Protection Against Blue Light.International journal of nanomedicine · 2021Article
- Article
- Toxicity of copper oxide nanoparticles: a review study.IET nanobiotechnology · 2020Review
- Autophagy Modulated by Inorganic Nanomaterials.Theranostics · 2020Review
- Nanoparticle Interactions with the Tumor Microenvironment.Bioconjugate chemistry · 2019Review
- Remote Magnetic Control of Autophagy in Mouse B-Lymphoma Cells with Iron Oxide Nanoparticles.Nanomaterials (Basel, Switzerland) · 2019Article
- Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment.Cellular and molecular life sciences : CMLS · 2019Review
- Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study.Scientific reports · 2019Article
- The impact of nanoparticle-driven lysosomal alkalinization on cellular functionality.Journal of nanobiotechnology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis and intracellular accumulation of nanoparticles can be responsible for this interesting phenomenon. Our results suggest dispersity-dependent autophagic effect as a common cellular response to nanoparticles, reveal the relationship between properties of nanoparticles and autophagy, and offer a new alternative way to modulate autophagy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.