Evidence map›Paper›PMID 26394780›Full record

ArticleWiener klinische Wochenschrift2016

Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients.

Gulhan Akbaba, Dilek Berker, Serhat Isık, Mazhar Muslum Tuna, Suha Koparal, Murat Vural, Fatma Meric Yılmaz, Canan Topcuoglu, Serdar Guler

Open access · greenAbstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Wiener klinische Wochenschrift, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gulhan AkbabaDepartment of Internal Medicine, Endocrinology and Metabolism, Mugla Sıtkı Kocman University School of Medicine, Mugla, Turkey. gulhanakcil@yahoo.com.tr.
Dilek BerkerClinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Serhat IsıkClinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Mazhar Muslum TunaClinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Suha KoparalClinics of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Murat VuralClinics of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Fatma Meric YılmazClinics of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Canan TopcuogluClinics of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Serdar GulerClinics of Endocrinology and Diseases of Metabolism, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Ankara Numune Eğitim ve Araştırma Hastanesi · TRMuğla University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubclinical hypothyroidism (SH) occurs when serum thyroid stimulating hormone (TSH) concentrations are raised and serum thyroid hormone concentrations are normal. The effect of SH on the proinflammatory adipose cytokine releasing visceral adipose tissue (VAT) is not clear. The aim of this study is to identify the difference between the pre and posttreatment levels of VAT, leptin, and resistin in SH patients.

methodsThere were 51 SH patients and 43 age- and gender-matched healthy subjects included in the study. Thyroid functions, biochemical tests, leptin, resistin, and visceral and subcutaneous fat measurements were made. The measurements were repeated in the SH group in the third month following L-thyroxin treatment.

resultsInitially, high sensitivity C-reactive protein, carotid artery intima-media thickness (mm), leptin, and resistin levels were significantly higher in the SH group compared to the controls, while the other parameters were similar. While no correlation was observed between TSH levels and adipokines, a positive correlation was detected between waist circumference and leptin levels (r = 0.549, p < 0.01). Visceral adipose tissue was positively correlated to age, waist circumference, and leptin levels, but negatively correlated to free thyroxin (T4) levels (r = 0.419, p = 0.009; r = 0.794, p < 0.01; r = 0.515, p < 0.01 and r = - 0.416, p = 0.009, respectively). A significant decrease was observed in VAT volume, leptin, and resistin levels of SH patients following levothyroxine treatment. Conclusion The reduced VAT volume, leptin, and resistin levels in SH patients following treatment may support the idea that TSH affects adipose tissue functions.

Indexed as

AdultAsymptomatic DiseasesBiomarkersFemaleHormone Replacement TherapyHumansHypothyroidismIntra-Abdominal FatLeptinMaleReproducibility of ResultsResistinSensitivity and SpecificityThyroxineTreatment OutcomeBiomarkersLeptinResistinThyroxineLeptinResistinSubclinical hypothyroidismThyroid stimulating hormoneVisceral adipose tissue

Identifiers

PMID26394780
OpenAlexW1699796818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.