SynthesisBMC medicine2015
Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis.
Synthesis in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05464940 (Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction in Patients With Paroxysmal Atrial Fibrillation), which is not on this map. Cited by 29 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction in Patients With Paroxysmal Atrial Fibrillation: The COFFEE-AF Trial
Who cites it
29 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Coffee, caffeine, and cardiovascular health: navigating risks and benefits-an updated systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- Association of Coffee Consumption With Atrial Fibrillation Risk: An Updated Dose-Response Meta-Analysis of Prospective Studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Environmental factors, serum biomarkers and risk of atrial fibrillation: an exposure-wide umbrella review of meta-analyses.European journal of epidemiology · 2020Pooled it
- Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.BMJ (Clinical research ed.) · 2017Pooled it
- Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose-Response Meta-Analysis.Nutrients · 2017Pooled it
- Association of coffee consumption with diabetes mellitus and gestational diabetes mellitus.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Recent-onset atrial fibrillation: challenges and opportunities.European heart journal · 2026Review
- Highlights of Cardiovascular Disease Prevention Studies Presented at the 2025 American Heart Association Scientific Sessions.Current atherosclerosis reports · 2026Review
- The Role of Xenobiotic Caffeine on Cardiovascular Health: Promises and Challenges.Journal of xenobiotics · 2025Review
- Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation.BMC medicine · 2024Observational
- Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.GeroScience · 2024Review
- Beverages - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Mediterranean diet and atrial fibrillation: a case-control study from China.Frontiers in nutrition · 2024Article
- Sex Related Differences in the Complex Relationship between Coffee, Caffeine and Atrial Fibrillation.Nutrients · 2023Review
- Coffee consumption and associations with blood pressure, LDL-cholesterol and echocardiographic measures in the general population.Scientific reports · 2023Article
- Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review.Pharmaceutical medicine · 2023Review
- Atrial fibrillation: primary prevention, secondary prevention, and prevention of thromboembolic complications: part 1.Frontiers in cardiovascular medicine · 2023Review
- Coffee and cardiac arrhythmias: Up-date review of the literature and clinical studies.Cardiology journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether coffee consumption affects the risk of developing atrial fibrillation (AF) remains unclear. We sought to investigate the association between coffee consumption and incidence of AF in two prospective cohorts, and to summarize available evidence using a meta-analysis.
methodsOur study population comprised 41,881 men in the Cohort of Swedish Men and 34,594 women in the Swedish Mammography Cohort who had provided information on coffee consumption in 1997 and were followed up for 12 years. Incident cases of AF were ascertained by linkage with the Swedish Hospital Discharge Register. For the meta-analysis, prospective studies were identified by searching PubMed and Embase through 22 July 2015, and by reviewing the reference lists of retrieved articles. Study-specific relative risks were combined using a random effects model.
resultsWe ascertained 4,311 and 2,730 incident AF cases in men and women, respectively, in the two cohorts. Coffee consumption was not associated with AF incidence in these cohort studies. The lack of association was confirmed in a meta-analysis, including six cohort studies with a total of 10,406 cases of AF diagnosed among 248,910 individuals. The overall relative risk (95% confidence interval) of AF was 0.96 (0.84-1.08) for the highest versus lowest category of coffee consumption, and 0.99 (0.94-1.03) per 2 cups/day increment of coffee consumption.
conclusionsWe found no evidence that coffee consumption is associated with increased risk of AF.
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