ArticlePloS one2015
Cardiac Autonomic Nervous System Activation and Metabolic Profile in Young Children: The ABCD Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Smartphone addiction and metabolic health risk in pediatrics.European journal of pediatrics · 2026Review
- Adiposity and cardiac autonomic function in children with a family history of obesity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Observational
- Maternal Weight Gain during Pregnancy and the Developing Autonomic Nervous System-Possible Impact of GDM.Nutrients · 2022Article
- Heart rate variability in children: methodological issues and clinical applications.Archivos de cardiologia de Mexico · 2022Article
- Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke.Frontiers in aging neuroscience · 2022Review
- Review
- A Close Examination of the Use of Systolic Time Intervals in the Calculation of Impedance Derived Cardiac Autonomic Balance and Regulation.Frontiers in neuroscience · 2021Article
- Feeding During Infancy: Interpersonal Behavior, Physiology, and Obesity Risk.Child development perspectives · 2020Article
- Measuring Heart Rate Variability Using Commercially Available Devices in Healthy Children: A Validity and Reliability Study.European journal of investigation in health, psychology and education · 2020Article
- Parasympathetic Response Patterns are Associated with Metabolic Syndrome Among Older Women but Not Men.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- Associations of immunometabolic risk factors with symptoms of depression and anxiety: The role of cardiac vagal activity.Brain, behavior, and immunity · 2018Article
- Effect of excessive infant crying on resting BP, HRV and cardiac autonomic control in childhood.PloS one · 2018Observational
- Relation of Heart Rate and its Variability during Sleep with Age, Physical Activity, and Body Composition in Young Children.Frontiers in physiology · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn adults, increased sympathetic and decreased parasympathetic nervous system activity are associated with a less favorable metabolic profile. Whether this is already determined at early age is unknown. Therefore, we aimed to assess the association between autonomic nervous system activation and metabolic profile and its components in children at age of 5-6 years.
methodsCross-sectional data from an apparently healthy population (within the ABCD study) were collected at age 5-6 years in 1540 children. Heart rate (HR), respiratory sinus arrhythmia (RSA; parasympathetic activity) and pre-ejection period (PEP; sympathetic activity) were assessed during rest. Metabolic components were waist-height ratio (WHtR), systolic blood pressure (SBP), fasting triglycerides, glucose and HDL-cholesterol. Individual components, as well as a cumulative metabolic score, were analyzed.
resultsIn analysis adjusted for child's physical activity, sleep, anxiety score and other potential confounders, increased HR and decreased RSA were associated with higher WHtR (P< 0.01), higher SBP (p<0.001) and a higher cumulative metabolic score (HR: p < 0.001; RSA: p < 0.01). Lower PEP was only associated with higher SBP (p <0.05). Of all children, 5.6% had 3 or more (out of 5) adverse metabolic components; only higher HR was associated with this risk (per 10 bpm increase: OR = 1.56; p < 0.001).
conclusionsThis study shows that decreased parasympathetic activity is associated with central adiposity and higher SBP, indicative of increased metabolic risk, already at age 5-6 years.
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