ArticlePloS one2015
Cough Aerosol Cultures of Mycobacterium tuberculosis: Insights on TST / IGRA Discordance and Transmission Dynamics.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis.Journal of aerosol science · 2025Article
- Differentially culturableJournal of medical microbiology · 2025Article
- Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles.Nature communications · 2024Article
- The Titanic question in TB control: Should we worry about the bummock?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Tuberculosis Infectiousness is Associated with Distinct Clinical and Inflammatory Profiles.Research square · 2024Article
- Association ofJournal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023Review
- Transmission of tuberculosis in an incarcerated population during the subclinical period: A cross-sectional study in Qingdao, China.Frontiers in public health · 2023Article
- Ferrets as a model for tuberculosis transmission.Frontiers in cellular and infection microbiology · 2022Article
- Particle Dynamics and Bioaerosol Viability of Aerosolized Bacillus Calmette-Guérin Vaccine Using Jet and Vibrating Mesh Clinical Nebulizers.Journal of aerosol medicine and pulmonary drug delivery · 2022Article
- Resistance to Mycobacterium tuberculosis Infection Among Household Contacts: A Multinational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Article
- Epidemiological and genomic determinants of tuberculosis outbreaks in First Nations communities in Canada.BMC medicine · 2018Article
- Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil.BMC infectious diseases · 2017Article
- Innovative Methods to Manage, Detect, and Prevent Tuberculosis.American journal of respiratory and critical care medicine · 2017Article
- Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis.PloS one · 2017Article
- Cough Aerosols of Mycobacterium tuberculosis in the Prediction of Incident Tuberculosis Disease in Household Contacts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe diagnosis of latent tuberculosis (TB) infection (LTBI) is complicated by the absence of a gold standard. Discordance between tuberculin skin tests (TST) and interferon gamma release assays (IGRA) occurs in 10-20% of individuals, but the underlying mechanisms are poorly understood.
methodsWe analyzed data from a prospective household contact study that included cough aerosol culture results from index cases, environmental and contact factors. We assessed contacts for LTBI using TST and IGRA at baseline and six weeks. We examined TST/IGRA discordance in qualitative and quantitative analyses, and used multivariable logistic regression analysis with generalized estimating equations to analyze predictors of discordance. MEASUREMENTS AND
resultsWe included 96 TB patients and 384 contacts. Discordance decreased from 15% at baseline to 8% by six weeks. In adjusted analyses, discordance was related to less crowding (p = 0.004), non-cavitary disease (OR 1.41, 95% CI: 1.02-1.96; p = 0.03), and marginally with BCG vaccination in contacts (OR 1.40, 95% CI: 0.99-1.98, p = 0.06).
conclusionsWe observed significant individual variability and temporal dynamism in TST and IGRA results in household contacts of pulmonary TB cases. Discordance was associated with a less intense infectious exposure, and marginally associated with a BCG-mediated delay in IGRA conversion. Cough aerosols provide an additional dimension to the assessment of infectiousness and risk of infection in contacts.
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