ArticleeLife2015
Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Application ofBiomolecules & therapeutics · 2026Review
- Inefficacy of a novel osmotic associative learning assay in C. elegans.BMC research notes · 2026Article
- A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans.Aging cell · 2025Article
- Investigating the Structural Basis of Diacetyl Recognition by the G-Protein-Coupled Receptor ODR-10 inThe journal of physical chemistry. B · 2025Article
- Probiotic Modulation in Aging: Strain-Specific Geroprotective Effects inInternational journal of molecular sciences · 2025Article
- Aberrant neuronal hyperactivation causes an age-dependent behavioral decline inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intricate response dynamics enhances stimulus discrimination in the resource-limited C. elegans chemosensory system.BMC biology · 2024Article
- Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans.Scientific reports · 2024Article
- Article
- The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans.Current biology : CB · 2023Article
- Functional imaging and quantification of multineuronal olfactory responses inScience advances · 2023Article
- Recent Advances in Life History Transition with Nematode-Trapping FungusPathogens (Basel, Switzerland) · 2023Review
- Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.Biogerontology · 2022Article
- Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance ineLife · 2022Article
- Modelling learning in Caenorhabditis elegans chemosensory and locomotive circuitry for T-maze navigation.The European journal of neuroscience · 2022Article
- Redundant neural circuits regulate olfactory integration.PLoS genetics · 2022Article
- Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans.PLoS computational biology · 2021Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing.Nature communications · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the food odor benzaldehyde (BZ) and release insulin-like peptides and acetylcholine, respectively, which are required for odor-evoked responses in secondary neurons, ASEL and AWB. Consistently, both primary and secondary neurons are required for BZ attraction. Unexpectedly, this combinatorial code is altered in aged animals: odor-evoked activity in secondary, but not primary, olfactory neurons is reduced. Moreover, experimental manipulations increasing neurotransmission from primary neurons rescues aging-associated neuronal deficits. Finally, we correlate the odor responsiveness of aged animals with their lifespan. Together, these results show how odors are encoded by primary and secondary neurons and suggest reduced neurotransmission as a novel mechanism driving aging-associated sensory neural activity and behavioral declines.
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