Evidence map›Paper›PMID 26393645›Full record

Trial reportNutrients2015

The Effects of a Low-Carbohydrate Diet vs. a Low-Fat Diet on Novel Cardiovascular Risk Factors: A Randomized Controlled Trial.

Tian Hu, Lu Yao, Kristi Reynolds, Paul K Whelton, Tianhua Niu, Shengxu Li, Jiang He, Lydia A Bazzano

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tian HuDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA. thu1@tulane.edu.
Lu YaoDivision of Epidemiology and Community Health, University of Minnesota, 1300 S 2nd Street, Suite 300, Minneapolis, MN 55454, USA. yaoxx097@umn.edu.
Kristi ReynoldsDepartment of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles, 2nd Floor, Pasadena, CA 91101, USA. Kristi.Reynolds@kp.org.
Paul K WheltonDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA. pkwhelton@gmail.com.
Tianhua NiuDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2001, New Orleans, LA 70112, USA. tniu@tulane.edu.
Shengxu LiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA. sli10@tulane.edu.
Jiang HeDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA. jhe@tulane.edu.
Lydia A BazzanoDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA. lbazzano@tulane.edu.
Tulane University · USKaiser Permanente · USUniversity of Minnesota · US

Funding

TULANE COBRE: TRANSGENIC &GENE-TARGETED ANIMAL COREP20RR017659 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI PRIETO, MINOLFA C · 2002 to 2011
$22.1M
NCRR NIH HHS P20 RR017659NCRR NIH HHS P20-RR017659
6 · The paper itself

Abstract

Increasing evidence supports a low-carbohydrate diet for weight loss and improvement in traditional cardiovascular disease (CVD) markers. Effects on novel CVD markers remain unclear. We examined the effects of a low-carbohydrate diet (<40 g/day; n = 75) versus a low-fat diet (<30% kcal/day from total fat, <7% saturated fat; n = 73) on biomarkers representing inflammation, adipocyte dysfunction, and endothelial dysfunction in a 12 month clinical trial among 148 obese adults free of diabetes and CVD. Participants met with a study dietitian on a periodic basis and each diet group received the same behavioral curriculum which included dietary instruction and supportive counseling. Eighty percent of participants completed the intervention. At 12 months, participants on the low-carbohydrate diet had significantly greater increases in adiponectin (mean difference in change, 1336 ng/mL (95% CI, 342 to 2330 ng/mL); p = 0.009) and greater decreases in intercellular adhesion molecule-1 concentrations (-16.8 ng/mL (-32.0 to -1.6 ng/mL); p = 0.031) than those on the low-fat diet. Changes in other novel CVD markers were not significantly different between groups. In conclusion, despite the differences in weight changes on diets, a low-carbohydrate diet resulted in similar or greater improvement in inflammation, adipocyte dysfunction, and endothelial dysfunction than a standard low-fat diet among obese persons.

Indexed as

Diet, Carbohydrate-RestrictedDiet, Fat-RestrictedAdipocytesAdiponectinAdultAgedBiomarkersCardiovascular DiseasesCounselingEndothelial CellsEnergy IntakeFemaleHumansInflammation MediatorsIntercellular Adhesion Molecule-1LipidsAdiponectinADIPOQ protein, humanBiomarkersICAM1 protein, humanInflammation MediatorsIntercellular Adhesion Molecule-1Lipidsadipocytokinesclinical trialdietary carbohydrateendothelial dysfunctioninflammationnutritionobesity

Identifiers

PMID26393645
PMCPMC4586572
OpenAlexW1881285741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.