ArticleMolecules (Basel, Switzerland)2015
Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The anti-inflammatory properties of Acanthus Ebracteatus, Barleria Lupulina and Clinacanthus Nutans: a systematic review.Molecular biology reports · 2020Pooled it
- Immunomodulatory Activities of Thai Herbs and the Druggability of Their Bioactive Constituents: A Comprehensive Review for Potential Phytopharmaceutical Product Development.Drug design, development and therapy · 2025Review
- Metabolic profiling and antioxidant activity of fenugreek seeds cultivars 'Giza 2' and 'Giza 30' compared to other geographically-related seeds.Food chemistry: X · 2024Article
- Article
- Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma.Discover oncology · 2024Article
- Synergistic effects of combined cisplatin andJournal of Taibah University Medical Sciences · 2023Article
- Antiviral and Immunomodulatory Activities ofInternational journal of molecular sciences · 2023Review
- Anti-Inflammatory Activity of Glyceryl 1,3-Distearate Identified fromAntibiotics (Basel, Switzerland) · 2023Article
- CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.Bioengineered · 2022Article
- A Narrative Review on the Phytochemistry, Pharmacology and Therapeutic Potentials ofMolecules (Basel, Switzerland) · 2021Review
- Recent Advancement in Anticancer Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Article
- Subacute Oral Administration ofMolecules (Basel, Switzerland) · 2020Article
- Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4 T1 tumor-bearing mice.BMC complementary and alternative medicine · 2019Article
- In Vitro Cytotoxic Activity of Clinacanthus nutans Leaf Extracts Against HeLa CellsAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Water extract of Clinacanthus nutans leaves exhibits in vitro, ex vivo and in vivo anti-angiogenic activities in endothelial cell via suppression of cell proliferation.BMC complementary and alternative medicine · 2018Article
- A Comprehensive Review on Phytochemistry and Pharmacological Activities ofEvidence-based complementary and alternative medicine : eCAM · 2018Review
- Clinacanthus nutans: a review on ethnomedicinal uses, chemical constituents and pharmacological properties.Pharmaceutical biology · 2017Review
- Clinacanthus Nutans Hexane Extracts Induce Apoptosis Through a Caspase-Dependent Pathway in Human Cancer Cell LinesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons.Neuromolecular medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinacanthans nutans (Burm. f.) Lindau is a popular medicinal vegetable in Southern Asia, and its extracts have displayed significant anti-proliferative effects on cancer cells in vitro. However, the underlying mechanism for this effect has yet to be established. This study investigated the antitumor and immunomodulatory activity of C. nutans (Burm. f.) Lindau 30% ethanol extract (CN30) in vivo. CN30 was prepared and its main components were identified using high-performance liquid chromatography (HPLC) and mass spectrometry (LC/MS/MS). CN30 had a significant inhibitory effect on tumor volume and weight. Hematoxylin and eosin (H & E) staining and TUNEL assay revealed that hepatoma cells underwent significant apoptosis with CN30 treatment, while expression levels of proliferation markers PCNA and p-AKT were significantly decreased when treated with low or high doses of CN30 treatment. Western blot analysis of PAPR, caspase-3, BAX, and Bcl2 also showed that CN30 induced apoptosis in hepatoma cells. Furthermore, intracellular staining analysis showed that CN30 treatment increased the number of IFN-γ⁺ T cells and decreased the number of IL-4⁺ T cells. Serum IFN-γ and interleukin-2 levels also significantly improved. Our findings indicated that CN30 demonstrated antitumor properties by up-regulating the immune response, and warrants further evaluation as a potential therapeutic agent for the treatment and prevention of cancers.
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