ArticleMolecules (Basel, Switzerland)2015
Synthesis and Biological Activity of Isoflavone Derivatives from Chickpea as Potent Anti-Diabetic Agents.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Inhibitory Effects on the Polyol Pathway in Type 2 Diabetic Rats by Chickpea Flavonoid Extract.Foods (Basel, Switzerland) · 2026Article
- New polyvinyl alcohol/gellan gum-based bioplastics with guava and chickpea extracts for food packaging.Scientific reports · 2023Article
- Nutritional and Nutraceutical Properties of Selected Pulses to Promote Gluten-Free Food Products.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Review
- Biochemical Profiling for Antioxidant and Therapeutic Potential of Pakistani Chickpea (Frontiers in plant science · 2021Article
- Medicinal Potential of Isoflavonoids: Polyphenols That May Cure Diabetes.Molecules (Basel, Switzerland) · 2020Review
- Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections.Plant foods for human nutrition (Dordrecht, Netherlands) · 2018Article
- Study of the Hypoglycemic Activity of Derivatives of Isoflavones fromEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A set of novel isoflavone derivatives from chickpea were synthesized. The structures of derivatives were identified by proton nuclear magnetic resonance (¹H-NMR), carbon-13 ((13)C)-NMR and mass spectrometry (MS) spectral analyses. Their anti-diabetic activities were evaluated using an insulin-resistant (IR) HepG2 cell model. Additionally, the structure-activity relationships of these derivatives were briefly discussed. Compounds 1c, 2h, 3b, and 5 and genistein exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells. In addition, the combinations of genistein, 2h, and 3b (combination 6) and of 3b, genistein, and 1c (combination 10) exhibited better anti-diabetic activity than the individual compounds. At the same dosage, there was no difference in effect between the combination 10 and the positive control (p > 0.05). Aditionally, we found the differences between the combination 10 and combination 6 for the protective effect of HUVEC (human umbilical vein endothelial cells) under high glucose concentration. The protective effects of combination 10 was stronger than combination 6, which suggested that combination 10 may have a better hypoglycemic activity in future studies. This study provides useful clues for the further design and discovery of anti-diabetic agents.
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