ArticleJournal of neurotrauma2016
Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury.
Article in Journal of neurotrauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of cross-sectional differences and longitudinal changes to the morphometry of the brain following paediatric traumatic brain injury.NeuroImage. Clinical · 2019Pooled it
- Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training.Brain structure & function · 2025Trial
- Regional brain volume prior to treatment is linked to outcome after cognitive rehabilitation in traumatic brain injury.NeuroImage. Clinical · 2022Trial
- Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.Journal of neurotrauma · 2021Trial
- Prediction of Post Traumatic Epilepsy Using MR-Based Imaging Markers.Human brain mapping · 2024Article
- Differences in Brain Volume in Military Service Members and Veterans After Blast-Related Mild TBI: A LIMBIC-CENC Study.JAMA network open · 2024Article
- Article
- Abnormal structural and functional network topological properties associated with left prefrontal, parietal, and occipital cortices significantly predict childhood TBI-related attention deficits: A semi-supervised deep learning study.Frontiers in neuroscience · 2023Article
- Brain volume abnormalities and clinical outcomes following paediatric traumatic brain injury.Brain : a journal of neurology · 2022Article
- Neuroanatomic Markers of Posttraumatic Epilepsy Based on MR Imaging and Machine Learning.AJNR. American journal of neuroradiology · 2022Article
- Topological Aberrance of Structural Brain Network Provides Quantitative Substrates of Post-Traumatic Brain Injury Attention Deficits in Children.Brain connectivity · 2021Article
- Relationship of Cerebral Blood Flow to Cognitive Function and Recovery in Early Chronic Traumatic Brain Injury.Journal of neurotrauma · 2020Article
- An Image Registration-Based Morphing Technique for Generating Subject-Specific Brain Finite Element Models.Annals of biomedical engineering · 2020Article
- Developmental divergence of structural brain networks as an indicator of future cognitive impairments in childhood brain injury: Executive functions.Developmental cognitive neuroscience · 2020Article
- Stem Cell Therapy for Pediatric Traumatic Brain Injury.Frontiers in neurology · 2020Review
- Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Quantifying local tumor morphological changes with Jacobian map for prediction of pathologic tumor response to chemo-radiotherapy in locally advanced esophageal cancer.Physics in medicine and biology · 2018Article
- Whole Brain Magnetic Resonance Spectroscopic Determinants of Functional Outcomes in Pediatric Moderate/Severe Traumatic Brain Injury.Journal of neurotrauma · 2018Article
- Memory and the hippocampal formation following pediatric traumatic brain injury.Brain and behavior · 2017Article
- Diverging white matter trajectories in children after traumatic brain injury: The RAPBI study.Neurology · 2017Article
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Authors and funding
12 authors.
Funding
Abstract
Traumatic brain injury (TBI) can cause widespread and prolonged brain degeneration. TBI can affect cognitive function and brain integrity for many years after injury, often with lasting effects in children, whose brains are still immature. Although TBI varies in how it affects different individuals, image analysis methods such as tensor-based morphometry (TBM) can reveal common areas of brain atrophy on magnetic resonance imaging (MRI), secondary effects of the initial injury, which will differ between subjects. Here we studied 36 pediatric moderate to severe TBI (msTBI) participants in the post-acute phase (1-6 months post-injury) and 18 msTBI participants who returned for their chronic assessment, along with well-matched controls at both time-points. Participants completed a battery of cognitive tests that we used to create a global cognitive performance score. Using TBM, we created three-dimensional (3D) maps of individual and group differences in regional brain volumes. At both the post-acute and chronic time-points, the greatest group differences were expansion of the lateral ventricles and reduction of the lingual gyrus in the TBI group. We found a number of smaller clusters of volume reduction in the cingulate gyrus, thalamus, and fusiform gyrus, and throughout the frontal, temporal, and parietal cortices. Additionally, we found extensive associations between our cognitive performance measure and regional brain volume. Our results indicate a pattern of atrophy still detectable 1-year post-injury, which may partially underlie the cognitive deficits frequently found in TBI.
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