ArticleInvestigative ophthalmology & visual science2015
Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Dry eye disease and psychiatric disorders: A systematic review and meta-analysis.European journal of ophthalmology · 2022Pooled it
- Association between dry eye disease and depression: An umbrella review.Frontiers in public health · 2022Pooled it
- The effects of vitamin d replacement therapy on ocular surface health in children with vitamin d deficiency.Japanese journal of ophthalmology · 2026Article
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study.JMIR research protocols · 2025Article
- Exploring the Influence ofGenes · 2024Article
- Dry Eye Disease: What Is the Role of Vitamin D?International journal of molecular sciences · 2023Review
- A, B, C's of Trk Receptors and Their Ligands in Ocular Repair.International journal of molecular sciences · 2022Review
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence.Human genomics · 2020Review
- Association Between Single Nucleotide Polymorphisms in the Vitamin D Receptor and Incidence of Dry Eye Disease in Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Enriched environment alleviates stress-induced dry-eye through the BDNF axis.Scientific reports · 2019Article
- Lower Serum Vitamin D Level Was Associated with Risk of Dry Eye Syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Association of dry eye disease with psychiatric or neurological disorders in elderly patients.Clinical interventions in aging · 2017Review
- Expression of Vitamin D Receptor and Vitamin D Receptor Gene Polymorphisms (BsmI, FokI, and TaqI) in Patients with Pterygium.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo identify single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF), vitamin D receptor (VDR), and DNASE1 genes that may be associated with dry eye disease (DED), and determine whether this association varies by the presence of depression.
methodsA case-control study was performed with 64 DED cases and 51 controls. We collected 2 mL of saliva following a routine eye exam. Genotyping was performed using both custom and predesigned TaqMan SNP genotyping assays for 12 hypothesized SNPs. Genotype and allele frequencies of cases and controls were evaluated. Odds ratios were calculated for allele frequencies. Stratified analysis was performed to determine if the association between SNPs and DED varied by depression status.
resultsA total of 18% of cases had the minor allele A of Val66Met (rs6265) SNP in the BDNF gene compared with 9% of the controls (P = 0.05). Odds ratio was 2.22. Two SNPs (Fokl-rs2228570 and Apal-rs7975232) in the VDR genes also varied between DED cases and controls. Cases were 1.72 and 1.66 times more likely to have the minor allele A in rs2228570 and rs7975232, respectively, than controls (P = 0.06 for both). While not statistically significant, among patients with depression, DED cases were 3.93 times more likely to have the minor allele A of the Val66Met SNP compared to controls.
conclusionsThis pilot study showed that Val66Met in the BDNF gene and two SNPs, Fokl and Apal, in the VDR gene may potentially be associated with DED. Additionally, the association between DED and Val66Met may vary by depression status.
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