ArticleJournal of clinical and diagnostic research : JCDR2015
Chromosomal Abnormalities in Infertile Men from Southern India.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Evidence-based guideline: unexplained infertility†.Human reproduction (Oxford, England) · 2023Guideline
- LncRNAiScience · 2026Article
- When Genetics Meet Hormones: Infertility and Normogonadotropic Hypogonadism From Robertsonian Translocation (14;21).Cureus · 2025Article
- Diagnostic algorithm in men suspected with nonobstructive azoospermia.Asian journal of andrology · 2025Review
- Article
- Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility.Archives of Iranian medicine · 2023Article
- Correlation between Cytogenetic Findings and Spermatogenic Failure in Bulgarian Infertile Men.Life (Basel, Switzerland) · 2022Article
- Reproductive Chances of Men with Azoospermia Due to Spermatogenic Dysfunction.Journal of clinical medicine · 2021Review
- Y chromosome microdeletion and cytogenetic findings in male infertility: A cross-sectional descriptive study.International journal of reproductive biomedicine · 2021Article
- Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature.Medicine · 2019Article
- A Familial Case Report of a 13;22 Chromosomal Translocation with Recurrent Intracytoplasmic Sperm Injection Failure.Balkan journal of medical genetics : BJMG · 2018Article
- Clinical Features of Chromosome 6 Translocation in Male Carriers: A Report of 10 Cases and Review of the Literature.Medical science monitor : international medical journal of experimental and clinical research · 2018Review
- Male infertility associated with de novo pericentric inversion of chromosome 1.Turkish journal of urology · 2017Article
- Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples.Journal of assisted reproduction and genetics · 2017Article
- Y-chromosomal genes affecting male fertility: A review.Veterinary world · 2016Review
- Article
- A Case-Control Study Identifying the Frequency and Spectrum of Chromosomal Anomalies and Variants in a Cohort of 1000 Couples with a Known History of Recurrent Pregnancy Loss in the Eastern Region of India.Journal of human reproductive sciencesArticle
- The Spectrum of Chromosomal Abnormalities and Endocrine Profile of Male Infertility with Nonobstructive Semen Abnormality: A Case-Control Study.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveMale infertility has been associated with aneuploidies and structural chromosomal abnormalities, Yq microdeletions and specific gene mutations and/or polymorphisms. Besides genetic factors, any block in sperm delivery, endocrine disorders, testicular tumours, infectious diseases, medications, lifestyle factors and environmental toxins can also play a causative role. This study aimed to determine the constitutional karyotype in infertile males having normal female partners in a south Indian population. MATERIALS AND
methodsA total of 180 men with a complaint of primary infertility ranging from 1 to 25 years were screened for chromosomal abnormalities through conventional analysis of GTG-banded metaphases from cultured lymphocytes.
resultsFour individuals were diagnosed to have Klinefelter syndrome. Two cases exhibited reciprocal translocations and one showed a maternally inherited insertion. Polymorphisms were seen in sixty-seven patients (37.2%).
conclusionThe occurrence of chromosomal abnormalities in 4.6% and variants involving the heterochromatic regions of Y, chromosome 9 and the acrocentric chromosomes in 38.2% of the infertile men with an abnormal seminogram strongly reiterates the inclusion of routine cytogenetic testing and counselling in the diagnostic work-up prior to the use of assisted reproduction technologies.
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