Evidence map›Paper›PMID 26393019›Full record

ArticlePublic health action2013

Characteristics and treatment outcomes of tuberculosis retreatment cases in three regional hospitals, Uganda.

A Nakanwagi-Mukwaya, A J Reid, P I Fujiwara, F Mugabe, R J Kosgei, K Tayler-Smith, W Kizito, M Joloba

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In one paragraph

Article in Public health action, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic review of clinical outcomes on the WHO Category II retreatment regimen for tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018
    Pooled it
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  4. Relapse or Re-Infection, the Situation of Recurrent Tuberculosis in Eastern China.Frontiers in cellular and infection microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Nakanwagi-MukwayaInternational Union Against Tuberculosis and Lung Disease, Kampala, Uganda.
A J ReidMédecins Sans Frontières (MSF), Operational Centre Brussels, MSF Luxembourg, Luxembourg.
P I FujiwaraInternational Union Against Tuberculosis and Lung Disease, Paris, France.
F MugabeNational Tuberculosis and Leprosy Control Programme, Ministry of Health, Kampala, Uganda.
R J KosgeiDepartment of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya.
K Tayler-SmithMédecins Sans Frontières (MSF), Operational Centre Brussels, MSF Luxembourg, Luxembourg.
W KizitoMSF Operation Centre Brussels, Kenya Mission, Brussels, Belgium.
M JolobaNational Tuberculosis Reference Laboratory, Ministry of Health, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingThree regional referral hospitals in Uganda with a high burden of tuberculosis (TB) and human immunodeficiency virus (HIV) cases.

objectiveTo determine the treatment outcomes of TB retreatment cases and factors influencing these outcomes.

designA retrospective cohort study of routinely collected National Tuberculosis Programme data between 1 January 2009 and 31 December 2010.

resultsThe study included 331 retreatment patients (68% males), with a median age of 36 years, 93 (28%) of whom were relapse smear-positive, 21 (6%) treatment after failure, 159 (48%) return after loss to follow-up, 26 (8%) relapse smear-negative and 32 (10%) relapse cases with no smear performed. Treatment success rates for all categories of retreatment cases ranged between 28% and 54%. Relapse smear-positive (P = 0.002) and treatment after failure (P = 0.038) cases were less likely to have a successful treatment outcome. Only 32% of the retreatment cases received a Category II treatment regimen; there was no difference in treatment success among patients who received Category II or Category I treatment regimens (P = 0.73).

conclusionManagement of TB retreatment cases and treatment success for all categories in three referral hospitals in Uganda was poor. Relapse smear-positive or treatment after failure cases were less likely to have a successful treatment outcome.

Indexed as

ARTlaboratoryNTPoperational researchTB-HIV

Identifiers

PMID26393019
PMCPMC4463102

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.