ArticleSchizophrenia bulletin2016
Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia.
Article in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Mechanisms of parasite-mediated disruption of brain vessels.FEBS letters · 2026Review
- TIMP1 secretion induced bymSphere · 2025Article
- Analysis of the Correlation BetweenPathogens (Basel, Switzerland) · 2024Article
- Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.Clinical neuropsychiatry · 2022Article
- Latent Toxoplasma gondii infections are associated with elevated biomarkers of inflammation and vascular injury.BMC infectious diseases · 2021Article
- Toxoplasma gondii infection damages the perineuronal nets in a murine model.Memorias do Instituto Oswaldo Cruz · 2020Article
- Environmental risk factors for Toxoplasma gondii infections and the impact of latent infections on allostatic load in residents of Central North Carolina.BMC infectious diseases · 2018Article
- Toxoplasma gondii infection and common mental disorders in the Finnish general population.Journal of affective disorders · 2017Article
- CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects.Neuroscience bulletin · 2017Article
- From Toxoplasmosis to SchizophreniaFrontiers in psychiatry · 2017Article
- The known and missing links between Toxoplasma gondii and schizophrenia.Metabolic brain disease · 2016Review
- Besnoitia besnoiti infections activate primary bovine endothelial cells and promote PMN adhesion and NET formation under physiological flow condition.Parasitology research · 2016Article
- Hepatitis C-associated late-onset schizophrenia: a nationwide, population-based cohort study.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain unclear. Here we utilize a mouse model of chronic T gondii infection to identify protein biomarkers that are altered in serum and brain samples at 2 time points during chronic infection. Furthermore, we compare the identified biomarkers to those differing between "postmortem" brain samples from 35 schizophrenia patients and 33 healthy controls. Our findings suggest that T gondii infection causes substantial and widespread immune activation indicative of neural damage and reactive tissue repair in the animal model that partly overlaps with changes observed in the brains of schizophrenia patients. The overlapping changes include increases in C-reactive protein (CRP), interleukin-1 beta (IL-1β), interferon gamma (IFNγ), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular cell adhesion molecule 1 (VCAM-1). Potential roles of these factors in the pathogenesis of schizophrenia and toxoplasmosis are discussed. Identifying a defined set of markers shared within the pathophysiological landscape of these diseases could be a key step towards understanding their specific contributions to pathogenesis.
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