ArticleProceedings of the National Academy of Sciences of the United States of America2015
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans development.BMC biology · 2026Article
- Use ofBiomolecules · 2024Review
- ReducedAntioxidants (Basel, Switzerland) · 2023Article
- Microbiota-derived metabolites in regulating the development and physiology ofFrontiers in microbiology · 2023Review
- CYP35 family in Caenorhabditis elegans biological processes: fatty acid synthesis, xenobiotic metabolism, and stress responses.Archives of toxicology · 2022Review
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists.Developmental cell · 2022Article
- C. elegans: A biosensor for host-microbe interactions.Lab animal · 2021Review
- Xenobiotic metabolism and transport inJournal of toxicology and environmental health. Part B, Critical reviews · 2021Review
- Caenorhabditis elegans: a model to understand host-microbe interactions.Cellular and molecular life sciences : CMLS · 2020Review
- ROS-based lethality ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Delicate Balance between Bacterial Iron and Reactive Oxygen Species Supports Optimal C. elegans Development.Cell host & microbe · 2019Article
- Article
- C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions.Current opinion in biotechnology · 2017Review
- Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling.Nature cell biology · 2017Article
- Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling.The EMBO journal · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The microbial world presents a complex palette of opportunities and dangers to animals, which have developed surveillance and response strategies to hints of microbial intent. We show here that the mitochondrial homeostatic response pathway of the nematode Caenorhabditis elegans responds to Escherichia coli mutations that activate free radical detoxification pathways. Activation of C. elegans mitochondrial responses could be suppressed by additional mutations in E. coli, suggesting that C. elegans responds to products of E. coli to anticipate challenges to its mitochondrion. Out of 50 C. elegans gene inactivations known to mediate mitochondrial defense, we found that 7 genes were required for C. elegans response to a free radical producing E. coli mutant, including the bZip transcription factor atfs-1 (activating transcription factor associated with stress). An atfs-1 loss-of-function mutant was partially resistant to the effects of free radical-producing E. coli mutant, but a constitutively active atfs-1 mutant growing on wild-type E. coli inappropriately activated the pattern of mitochondrial responses normally induced by an E. coli free radical pathway mutant. Carbonylated proteins from free radical-producing E. coli mutant may directly activate the ATFS-1/bZIP transcription factor to induce mitochondrial stress response: feeding C. elegans with H2O2-treated E. coli induces the mitochondrial unfolded protein response, and inhibition of a gut peptide transporter partially suppressed C. elegans response to free radical damaged E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.