ArticleProceedings of the National Academy of Sciences of the United States of America2015
Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Expansion of B10 cellsInternational journal of molecular medicine · 2025Review
- The iNKT cell ligand α-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cells.Frontiers in immunology · 2024Article
- invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies.Frontiers in transplantation · 2024Review
- Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies.Frontiers in immunology · 2024Review
- T-betCell metabolism · 2022Article
- A therapeutic vaccine strategy to preventFrontiers in immunology · 2022Article
- Reading the room: iNKT cells influence B cell responses.Molecular immunology · 2021Review
- Immunosuppressive Mechanisms of Regulatory B Cells.Frontiers in immunology · 2021Review
- Harnessing NKT cells for vaccination.Oxford open immunology · 2021Review
- Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis.Frontiers in immunology · 2021Article
- Invariant natural killer T cells balance B cell immunity.Immunological reviews · 2021Review
- Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1.The EMBO journal · 2019Article
- Levels of regulatory T cells and invariant natural killer cells and their associations with regulatory B cells in patients with non-Hodgkin lymphoma.Molecular and clinical oncology · 2018Article
- Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen from Plasmodium chabaudi-Infected Mice.Infection and immunity · 2018Article
- CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells.Nature communications · 2018Article
- The Role of CD1d and MR1 Restricted T Cells in the Liver.Frontiers in immunology · 2018Review
- Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells.Frontiers in immunology · 2018Review
- Extrafollicular activities: perspectives on HIV infection, germinal center-independent maturation pathways, and KSHV-mediated lymphoproliferation.Current opinion in virology · 2017Review
- Message in a bottle from the tumor microenvironment: tumor-educated DCs instruct B cells to participate in immunosuppression.Cellular & molecular immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Successful induction of B-cell activation and memory depends on help from CD4+ T cells. Invariant natural killer T (iNKT) cells (glycolipid-specific, CD1d-restricted innate lymphocytes) provide both cognate (direct) and noncognate (indirect) helper signals to enhance B-cell responses. Both forms of iNKT-cell help induce primary humoral immune responses, but only noncognate iNKT-cell help drives humoral memory and plasma cells. Here, we show that iNKT cognate help for B cells is fundamentally different from the help provided by conventional CD4+ T cells. Cognate iNKT-cell help drives an early, unsustained germinal center B-cell expansion, less reduction of T follicular regulatory cells, an expansion of marginal zone B cells, and early increases in regulatory IL-10-producing B-cell numbers compared with noncognate activation. These results are consistent with a mechanism whereby iNKT cells preferentially provide an innate form of help that does not generate humoral memory and has important implications for the application of glycolipid molecules as vaccine adjuvants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.