Evidence map›Paper›PMID 26392507›Full record

ArticleAntimicrobial agents and chemotherapy2015

Chronic Invasive Aspergillus Sinusitis and Otitis with Meningeal Extension Successfully Treated with Voriconazole.

Marjolaine Morgand, Blandine Rammaert, Sylvain Poirée, Marie-Elisabeth Bougnoux, Hugo Tran, Romain Kania, Fabrice Chrétien, Gregory Jouvion, Olivier Lortholary

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Detecting serum galactomannan to diagnose acute invasive Aspergillus sinusitis: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Marjolaine MorgandUniversité Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris, France.
Blandine RammaertUniversité Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris, France.
Sylvain PoiréeUniversité Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service de Radiologie Adulte, AP-HP, Paris, France.
Marie-Elisabeth BougnouxUniversité Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service de Microbiologie, Unité de Parasitologie-Mycologie, AP-HP, Paris, France.
Hugo TranService d'Oto-rhino-laryngologie, Hôpital Lariboisière, AP-HP, Paris, France.
Romain KaniaService d'Oto-rhino-laryngologie, Hôpital Lariboisière, AP-HP, Paris, France.
Fabrice ChrétienInstitut Pasteur, Unité d'Histopathologie Humaine et Modèles Animaux, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Service de Neuropathologie, Centre Hospitalier Sainte Anne, AP-HP, Paris, France.
Gregory JouvionInstitut Pasteur, Unité d'Histopathologie Humaine et Modèles Animaux, Paris, France.
Olivier LortholaryUniversité Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris, France Institut Pasteur, Unité de Mycologie Moléculaire, CNRS URA3012, Paris, France olivier.lortholary@nck.aphp.fr.
Assistance Publique – Hôpitaux de Paris · FRHôpital Necker-Enfants Malades · FRUniversité Paris Cité · FRHôpital Lariboisière · FRInstitut Pasteur · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive aspergillosis (IA) is a severe disseminated fungal disease that occurs mostly in immunocompromised patients. However, central nervous system IA, combining meningitis and skull base involvement, does not occur only in groups with classic risk factors for IA; patients with chronic renal failure and diabetes mellitus are also at risk for more chronic forms. In both of our proven IA cases, voriconazole monotherapy was effective without surgery, and cerebrospinal fluid and serum 1,3-β-d-glucan test results were initially positive, in contrast to galactomannan antigen results.

Indexed as

AgedAntifungal AgentsAspergillus flavusAspergillus fumigatusbeta-GlucansCandida albicansChronic DiseaseDiabetes Mellitus, Type 2FemaleHumansMeningitis, FungalNeuroaspergillosisOtitisRenal Insufficiency, ChronicSinusitisTreatment OutcomeAntifungal Agentsbeta-1,3-glucanbeta-GlucansVoriconazole

Identifiers

PMID26392507
PMCPMC4649149
OpenAlexW2290224167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.