Evidence map›Paper›PMID 26392506›Full record

ArticleAntimicrobial agents and chemotherapy2015

Characterization of Tn3000, a Transposon Responsible for blaNDM-1 Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India.

Juliana Coutinho Campos, Maria José Félix da Silva, Paulo Roberto Nascimento dos Santos, Elaine Menezes Barros, Mayne de Oliveira Pereira, Bruna Mara Silva Seco, Cibele Massotti Magagnin, Leonardo Kalab Leiroz, Théo Gremen Mimary de Oliveira, Célio de Faria-Júnior and 6 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Coexistence of aInfection and drug resistance · 2026
    Article
  3. Emergence of carbapenem-resistantMicrobiology spectrum · 2025
    Article
  4. Article
  5. Evolution, dissemination, and genetic dynamics of the carbapenem resistance geneFrontiers in cellular and infection microbiology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Coexistence of plasmid-mediatedMicrobiology spectrum · 2024
    Article
  10. Genomic investigation of multispecies and multivariantInfection control and hospital epidemiology · 2024
    Article
  11. Molecular Epidemiology of Carbapenem-ResistantInternational journal of molecular sciences · 2024
    Article
  12. Microbiology spectrum · 2024
    Article
  13. Regional dissemination of NDM-1 producingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  14. Genomic investigation unveils high-risk ESBL producingCurrent research in microbial sciences · 2024
    Article
  15. Article
  16. Microorganisms · 2023
    Article
  17. First Identification of blaCurrent microbiology · 2023
    Article
  18. Article
  19. Characterization ofFrontiers in cellular and infection microbiology · 2023
    Article
  20. Coexistence ofMicrobiology spectrum · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juliana Coutinho CamposSchool of Pharmacy, University of São Paulo, São Paulo, Brazil.
Maria José Félix da SilvaFleury Group, Microbiology Section, Rio de Janeiro, Brazil.
Paulo Roberto Nascimento dos SantosChildren's Hospital, Rio de Janeiro, Brazil.
Elaine Menezes BarrosSchool of Pharmacy, University of São Paulo, São Paulo, Brazil.
Mayne de Oliveira PereiraSchool of Pharmacy, University of São Paulo, São Paulo, Brazil.
Bruna Mara Silva SecoSchool of Pharmacy, University of São Paulo, São Paulo, Brazil.
Cibele Massotti MagagninResearch Laboratory of Bacterial Resistance, Experimental Research Center, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Leonardo Kalab LeirozFleury Group, Microbiology Section, Rio de Janeiro, Brazil.
Théo Gremen Mimary de OliveiraLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.
Célio de Faria-JúniorNúcleo de Bacteriologia, GBM/Laboratório Central de Saúde Pública, Lacen-Brasilia, Brasília, Brazil.
Louise Teixeira CerdeiraCore Facility for Scientific Research, University of São Paulo, São Paulo, Brazil.
Afonso Luís BarthResearch Laboratory of Bacterial Resistance, Experimental Research Center, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Suely Carlos Ferreira SampaioMicrobiology Department, Federal University of São Paulo, São Paulo, Brazil.
Alexandre Prehn ZavasckiResearch Laboratory of Bacterial Resistance, Experimental Research Center, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil Infectious Diseases Service, Hospital de Clínicas de Porto, Porto Alegre, Brazil.
Laurent PoirelMedical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
Jorge Luiz Mello SampaioSchool of Pharmacy, University of São Paulo, São Paulo, Brazil Fleury Diagnostic Medicine, Microbiology Section, São Paulo, Brazil sampaio@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Enterobacteriaceae, the blaNDM genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the blaNDM-1 gene, one from each strain, showed that they belonged to incompatibility groups IncFIIK and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the blaNDM-1 gene may be transmitted by Tn3000 in different parts of the world.

Indexed as

Anti-Bacterial AgentsAztreonamBacterial ProteinsBase Sequencebeta-LactamasesBrazilConjugation, GeneticConserved SequenceDNA Transposable ElementsEnterobacterEnterobacteriaceae InfectionsEscherichia coliFosfomycinHumansIndiaMicrobial Sensitivity TestsAnti-Bacterial AgentsAztreonamBacterial Proteinsbeta-lactamase NDM-1beta-LactamasescarbapenemaseDNA Transposable ElementsFosfomycin

Identifiers

PMID26392506
PMCPMC4649174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.