Evidence map›Paper›PMID 26392488›Full record

ArticleAntimicrobial agents and chemotherapy2015

Reduced In Vitro Activity of Ceftaroline by Etest among Clonal Complex 239 Methicillin-Resistant Staphylococcus aureus Clinical Strains from Australia.

I J Abbott, A W J Jenney, C J Jeremiah, M Mirčeta, J P Kandiah, D C Holt, S Y C Tong, D W Spelman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Evaluation ofIranian journal of microbiology · 2021
    Article
  4. Review
  5. Antimicrobial resistance in methicillin-resistantAntimicrobial agents and chemotherapy · 2019
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

I J AbbottAlfred Hospital, Melbourne, Victoria, Australia iainabbott@gmail.com.
A W J JenneyAlfred Hospital, Melbourne, Victoria, Australia.
C J JeremiahAlfred Hospital, Melbourne, Victoria, Australia.
M MirčetaAlfred Hospital, Melbourne, Victoria, Australia.
J P KandiahMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
D C HoltMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
S Y C TongMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID http://orcid.org/0000-0002-1368-8356
D W SpelmanAlfred Hospital, Melbourne, Victoria, Australia.
The Alfred Hospital · AUCharles Darwin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total of 421 methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates were tested for ceftaroline susceptibility by Etest (bioMérieux). A multidrug resistant phenotype was found in 40.9%, and clonal complex 239 (CC239) was found in 33.5%. Ceftaroline nonsusceptibility (MIC, >1.0 μg/ml) was 16.9% overall. Nonsusceptibility was significantly higher in CC239 (41.1%, 58/141) and in isolates with a multidrug resistant phenotype (35.5%, 61/172) compared with comparators (P < 0.0001). Nonsusceptibility of common multidrug resistant MRSA clones limits the empirical use of ceftaroline for these infections.

Indexed as

Drug Resistance, Multiple, BacterialAnti-Bacterial AgentsAustraliaCeftarolineCephalosporinsClone CellsHumansMethicillinMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPhenotypeStaphylococcal InfectionsAnti-Bacterial AgentsCeftarolineCephalosporinsMethicillin

Identifiers

PMID26392488
PMCPMC4649159
OpenAlexW2338542408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.