ArticleBMJ case reports2015
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis.
Article in BMJ case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- [Prevalence of HTLV-1 infection in family members of index cases in PeruPrevalência familiar da infecção pelo HTLV-1 a partir de um caso índice no Peru].Revista panamericana de salud publica = Pan American journal of public health · 2026Article
- Review
- Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses.Journal of neurovirology · 2020Article
- Early-Onset HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.Pathogens (Basel, Switzerland) · 2020Article
- A high prevalence of human T-lymphotropic virus (HTLV 1/2) infection among Afro-descendants, Esmeraldas province, Ecuador - need for the implementation of surveys and control programs.Infection and drug resistance · 2019Article
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Authors and funding
4 authors.
Funding
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Abstract
Human T-lymphotropic virus 1 (HTLV-1) is frequent in Peru; an estimated 1-2% of the Peruvian population carry this retrovirus. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling disease that affects about 1% of the carriers of HTLV-1. It is not yet known why some HTLV-1-infected people develop HAM/TSP while others do not. In this case report, we present a family with an unusually high burden of HAM/TSP: 5 (the 2 parents and 3 of their children) of 7 HTLV-1 carriers developed the same disease. We describe the clinical presentation and discuss the clustering of disease against the current knowledge of the pathogenesis of HAM/TSP. Families such as this may hold the key to discovering which factors trigger the development of HAM/TSP.
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