Evidence map›Paper›PMID 26392368›Full record

SynthesisBehavior genetics2016

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

Tae-Hwi Schwantes-An, Juan Zhang, Li-Shiun Chen, Sarah M Hartz, Robert C Culverhouse, Xiangning Chen, Hilary Coon, Josef Frank, Helen M Kamens, Bettina Konte and 100 more

Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05563324 (Genetics of Self-injurious Behaviour), which is not on this map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05563324 completednot on this map

Genetics of Self-injurious Behaviour

TypeobservationalSponsorUniversity Medical Centre MariborRan2014 to 2018Enrolled234ConditionsSelf Injurious Behavior Without Suicidal Intent, Self-Injurious BehaviorArmsDNA extraction and genotyping of candidate genetic polymorphisms, self-assessment questionnaires
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

110 authors at 20 institutions in 8 countries.

Tae-Hwi Schwantes-AnDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.
Juan ZhangDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.
Li-Shiun ChenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Sarah M HartzDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Robert C CulverhouseDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Xiangning ChenDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Hilary CoonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Helen M KamensInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Bettina KonteDepartment of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
Leena KovanenDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Antti LatvalaDepartment of Public Health, University of Helsinki, Helsinki, 00014, Finland.
Lisa N LegrandDepartment of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
Brion S MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
Whitney E MelroyInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Mark W ReidOregon Research Institute, Eugene, OR, 97403, USA.
Jason D RobinsonDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Pei-Hong ShenSection of Human Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA.
Bao-Zhu YangDepartment of Psychiatry, Yale University, New Haven, CT, 06516, USA.
Judy A AndrewsOregon Research Institute, Eugene, OR, 97403, USA.
Paul AveyardDepartment of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, United Kingdom.
Olga BeltchevaDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, 1431, Sofia, Bulgaria.
Sandra A BrownDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Dale S CannonDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.
Sven CichonDepartment. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Norbert DahmenÖkumenisches Hainich-Klinikum, Mühlhausen/Thüringen, Germany.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Randwick, NSW, 2031, Australia.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Wolfgang GaebelUniversity of Düsseldorf, 40225, Düsseldorf, Germany.
Ina GieglingDepartment of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
Stephen J GlattDepartment of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Richard A GruczaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Jill HardinCenter for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.
Annette M HartmannDepartment of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Stefan HermsDepartment. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
Colin A HodgkinsonSection of Human Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA.
Per HoffmannDepartment. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
Hyman HopsOregon Research Institute, Eugene, OR, 97403, USA.
David HuizingaInstitute of Behavioral Science, University of Colorado, Boulder, CO, 80309, USA.
Marcus IsingMax-Planck-Institute of Psychiatry, 80804, Munich, Germany.
Eric O JohnsonBehavioral Health Research Division, Research Triangle Institute International, Durham, NC, 27709, USA.
Elaine JohnstoneDepartment of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
Radka P KanevaDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, 1431, Sofia, Bulgaria.
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Falk KieferDepartment of Addictive Behavior and Addiction Medicine, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Henry R KranzlerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ken S KrauterInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Orna LevranLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, 10065, USA.
Susanne LucaeMax-Planck-Institute of Psychiatry, 80804, Munich, Germany.
Michael T LynskeyAddictions Department, Institute of Psychiatry, King's College London, London, SE5 8BB, UK.
Wolfgang MaierUniversity of Bonn, 53113, Bonn, Germany.
Karl MannMedical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Nicholas G MartinDepartment of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, 4029, Australia.
Manuel MattheisenDepartment. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
Grant W MontgomeryDepartment of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, 4029, Australia.
Bertram Müller-MyhsokMax-Planck-Institute of Psychiatry, 80804, Munich, Germany.
Michael F MurphyChildhood Cancer Research Group, University of Oxford, Oxford, OX3 7LG, UK.
Michael C NealeDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Momchil A NikolovDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Denise NishitaCenter for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.
Markus M NöthenDepartment. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
John NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Timo PartonenDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Michele L PergadiaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Maureen ReynoldsDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Monika RidingerDepartment of Psychiatry, University Medical Center Regensburg, University of Regensburg, 8548, Regensburg, Germany.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
Noora Rouvinen-LagerströmDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Norbert ScherbaumAddiction Research Group at the Department of Psychiatry and Psychotherapy, LVR Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Christine SchmälMedical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Michael SoykaDepartment of Psychiatry, University of Munich, 3860, Munich, Germany.
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Michael SteffensResearch Department, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
Jens TreutleinDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Ming TsuangDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Tamara L WallDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Norbert WodarzDepartment of Psychiatry, University Medical Center Regensburg, University of Regensburg, 8548, Regensburg, Germany.
Vadim YuferovLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, 10065, USA.
Peter ZillUniversity of Munich, Munich, Germany.
Andrew W BergenCenter for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.
Jingchun ChenDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Paul M CinciripiniDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Marissa A EhringerInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Robert E FerrellDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Joel GelernterDepartment of Psychiatry, Yale University, New Haven, CT, 06516, USA.
David GoldmanSection of Human Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
Christian J HopferDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
Jaakko KaprioDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Mary Jeanne KreekLaboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, 10065, USA.
Ivo M KremenskyDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, 1431, Sofia, Bulgaria.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
Marcus R MunafòMRC Integrative Epidemiology Unit, UK Centre for Tobacco and Alcohol Studies, and School of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK.
Robert A PhilibertDepartment of Psychiatry, University of Iowa, Iowa City, IA, 52242, USA.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
Alec RoyPsychiatry Service, Department of Veteran Affairs, New Jersey VA Health Care System, East Orange, NJ, 07018, USA.
Dan RujescuDepartment of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
Sirkku T SaarikoskiDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
Gary E SwanDepartment of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94304, USA.
Alexandre A TodorovDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Michael M VanyukovDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Robert B WeissDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Nancy L SacconeDepartment of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA. nlims@genetics.wustl.edu.
Washington University in St. Louis · USUniversity of Colorado Boulder · USFinnish Institute for Health and Welfare · FICentral Institute of Mental Health · DEMedical University of Sofia · BGUniversity Hospital in Halle · DEVirginia Commonwealth University · USLife & Brain (Germany) · DEMax Planck Institute of Psychiatry · DENational Institute on Alcohol Abuse and Alcoholism · USOregon Research Institute · USRockefeller University · USSRI International · USUniversity of California San Diego · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Utah · USHeidelberg University · DEIndiana University – Purdue University Indianapolis · USLudwig-Maximilians-Universität München · DE

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4M
TRANSLATION MODULEP50DA005605 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RIDENOUR, TY A · 1989 to 2014
$25.7M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
University of Toronto Coordinating Genetics Core & Clinical Trial SiteU01DA020830 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CONTI, DAVID V · 2005 to 2014
$22.4M
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI STITZEL, JERRY A · 2001 to 2012
$17.3M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6M
British Heart FoundationCancer Research UK C53/A6281FDA HHS R01 FD003706Medical Research Council MC_UU_12013/6Medical Research Council MR/K023195/1NCATS NIH HHS UL1 TR001108NCI NIH HHS K07 CA092209NCI NIH HHS K07 CA92209NCI NIH HHS P01 CA089392NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA075356NCI NIH HHS R01 CA184781NCI NIH HHS R21 CA081649NCI NIH HHS R21 CA81649NHGRI NIH HHS 1 X01 HG005274-01NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS P01 HL072903NHLBI NIH HHS P01 HL72903NIAAA NIH HHS F31 AA013220NIAAA NIH HHS K01 AA019447NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P60 AA011998NIAAA NIH HHS R01 AA0011886NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R01 AA017889NIAAA NIH HHS R01 AA075356NIAAA NIH HHS R01 AA07728NIAAA NIH HHS R01 AA-09203NIAAA NIH HHS R01 AA11330NIAAA NIH HHS R01 AA11998NIAAA NIH HHS R01 AA13220NIAAA NIH HHS R01 AA13321NIAAA NIH HHS R01 AA13322NIAAA NIH HHS R01 AA17688NIAAA NIH HHS R21 AA013322NIAAA NIH HHS R37 AA009367NIAAA NIH HHS R37 AA012502NIAAA NIH HHS R37 AA-12502NIAAA NIH HHS U10 AA008401NIAMS NIH HHS R01 AR075356NIDA NIH HHS DA019498NIDA NIH HHS K01 DA019498NIDA NIH HHS K01 DA024758NIDA NIH HHS K01 DA24758NIDA NIH HHS K08 DA019951NIDA NIH HHS K08 DA030398NIDA NIH HHS K08 DA032680NIDA NIH HHS K24 DA032555NIDA NIH HHS P50 DA005130NIDA NIH HHS P50 DA005605NIDA NIH HHS P50 DA05130NIDA NIH HHS P60 DA011015NIDA NIH HHS R01 DA003706NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA011922NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012846NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA015789NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA018673NIDA NIH HHS R01 DA018823NIDA NIH HHS R01 DA019157NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA026911NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA036216NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA038076NIDA NIH HHS R01 DA11822NIDA NIH HHS R01 DA12690NIDA NIH HHS R01 DA12849NIDA NIH HHS R01 DA12854NIDA NIH HHS R01 DA18432NIDA NIH HHS R01 DA18673NIDA NIH HHS R01 U01 DA024417NIDA NIH HHS R21 DA038241NIDA NIH HHS R37 DA005147NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028793NIDA NIH HHS RC2 DA028909NIDA NIH HHS T32 DA017637NIDA NIH HHS U01 DA020830NIDA NIH HHS U01 DA024417NIMH NIH HHS R01 MH066140PHS HHS 141054PHS HHS 263278Wellcome Trust
6 · The paper itself

Abstract

The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, rs1799971 has on substance dependence risk, we conducted collaborative meta-analyses of 25 datasets with over 28,000 European-ancestry subjects. We investigated non-specific risk for "general" substance dependence, comparing cases dependent on any substance to controls who were non-dependent on all assessed substances. We also examined five specific substance dependence diagnoses: DSM-IV alcohol, opioid, cannabis, and cocaine dependence, and nicotine dependence defined by the proxy of heavy/light smoking (cigarettes-per-day >20 vs. ≤ 10). The G allele showed a modest protective effect on general substance dependence (OR = 0.90, 95% C.I. [0.83-0.97], p value = 0.0095, N = 16,908). We observed similar effects for each individual substance, although these were not statistically significant, likely because of reduced sample sizes. We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances. This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAdolescentAdultAllelesCase-Control StudiesChildCohort StudiesGene FrequencyHumansMalePolymorphism, Single NucleotideReceptors, Opioid, muSample SizeSubstance-Related DisordersWhite PeopleOPRM1 protein, humanReceptors, Opioid, muAddictionGenetic associationOpioid receptorOPRM1Single nucleotide polymorphism (SNP)Substance dependence

Identifiers

PMID26392368
PMCPMC4752855
OpenAlexW1951822496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.