Evidence map›Paper›PMID 26392197›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2016

Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT.

Shu Yokota, Mohamed Mouden, Jan Paul Ottervanger, Elsemiek Engbers, Siert Knollema, Jorik R Timmer, Pieter L Jager

Abstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Is the CZT technology the future of nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  4. Advanced technology in the risk stratification-based strategy: The way forward to keep going.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  5. CZT camera systems may provide better risk stratification for low-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  6. Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning.European journal of nuclear medicine and molecular imaging · 2021
    Article
  7. Article
  8. Article
  9. Assessment of four different cardiac softwares for evaluation of LVEF with CZT-SPECT vs CMR in 48 patients with recent STEMI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  10. Does fractional flow reserve overestimate severity of LAD lesions?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  11. Article
  12. Article
  13. Getting it right the first time: Stress-only MPI in the ER.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  14. The time is now: Dose reduction for myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  15. Effect of a patient-specific minimum activity in stress myocardial perfusion imaging using CZT-SPECT: Prognostic value, radiation dose, and scan outcome.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  16. SPECT: Workhorse of state of the art nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  17. Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
  18. Review
  19. Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shu YokotaDepartment of Cardiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB JW, Zwolle, The Netherlands.
Mohamed MoudenDepartment of Cardiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB JW, Zwolle, The Netherlands. m.mouden@isala.nl.
Jan Paul OttervangerDepartment of Cardiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB JW, Zwolle, The Netherlands.
Elsemiek EngbersDepartment of Cardiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB JW, Zwolle, The Netherlands.
Siert KnollemaDepartment of Nuclear Medicine, Isala Hospital, Zwolle, The Netherlands.
Jorik R TimmerDepartment of Cardiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB JW, Zwolle, The Netherlands.
Pieter L JagerDepartment of Nuclear Medicine, Isala Hospital, Zwolle, The Netherlands.
Isala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSingle photon emission computed tomography (SPECT) myocardial perfusion imaging has proven to have prognostic importance in patients with suspected stable coronary artery disease (CAD). The recently introduced ultrafast cadmium zinc telluride (CZT)-based gamma cameras have been associated with less equivocal findings and more normal interpretations, allowing stress-only imaging to be performed more often. However, it is yet unclear whether normal stress-only CZT SPECT has comparable prognostic value as normally interpreted stress-only conventional SPECT.

methodsThe study population consisted of 1,650 consecutive patients without known CAD with normal stress-only myocardial perfusion results with either conventional (n = 362) or CZT SPECT (n = 1,288). The incidence of major adverse cardiac events (MACE, all-cause death, non-fatal myocardial infarction and/or coronary revascularization) was compared between the conventional SPECT and CZT SPECT groups. Multivariable analyses using the Cox model were used to adjust for differences in baseline variables.

resultsPatients scanned with CZT were less often male (33 vs 39 %), had less often hypercholesterolaemia (41 vs 50 %) and had more often a family history of CAD (57 vs 49 %). At a median follow-up time of 37 months (interquartile range 28-45 months) MACE occurred in 68 patients. The incidence of MACE was 1.5 %/year in the CZT group, compared to 2.0 %/year in the conventional group (p = 0.08). After multivariate analyses, there was a trend to a lower incidence of MACE in the CZT SPECT group (hazard ratio 0.61, 95 % confidence interval 0.35-1.04, p = 0.07).

conclusionThe prognostic value of normal stress-only CZT SPECT is at least comparable and may be even better than that of normal conventional stress SPECT.

Indexed as

CadmiumMyocardial Perfusion ImagingRadiopharmaceuticalsTelluriumTomography, Emission-Computed, Single-PhotonZincAgedCoronary Artery DiseaseExercise TestFemaleHumansMaleMiddle AgedCadmiumCdZnTeRadiopharmaceuticalsTelluriumZincCadmium zinc tellurideMyocardial perfusion imagingPrognosisSingle photon emission computed tomographyStable coronary artery diseaseStress-only imaging

Identifiers

PMID26392197
OpenAlexW2178222515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.