ArticleMolecular imaging and biology2016
Chemical Exchange Saturation Transfer (CEST) MR Technique for Liver Imaging at 3.0 Tesla: an Evaluation of Different Offset Number and an After-Meal and Over-Night-Fast Comparison.
Article in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Human liver CEST imaging at 7 T: Impact ofMagnetic resonance in medicine · 2025Article
- Feasibility of Sodium and Amide Proton Transfer-Weighted Magnetic Resonance Imaging Methods in Mild Steatotic Liver Disease.Tomography (Ann Arbor, Mich.) · 2025Article
- CESTsimu: An open-source GUI for spectral and spatial CEST simulation.Magnetic resonance in medicine · 2025Article
- In vivo imaging of glycogen in human muscle.Nature communications · 2024Article
- AMPED study: Protocol for a randomized controlled trial of different doses of aerobic exercise training.Hepatology communications · 2024Article
- Image quality assessment and feasibility of three-dimensional amide proton transfer-weighted imaging for hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Reproducibility of APT-weighted CEST-MRI at 3T in healthy brain and tumor across sessions and scanners.Scientific reports · 2023Article
- Using endogenous glycogen as relaxation agent for imaging liver metabolism by MRI.Fundamental research · 2023Article
- An update on liver chemical exchange saturation transfer imaging with a focus on clinical translation.Quantitative imaging in medicine and surgery · 2023Article
- Radiofrequency labeling strategies in chemical exchange saturation transfer MRI.NMR in biomedicine · 2023Review
- CEST-MRI for body oncologic imaging: are we there yet?NMR in biomedicine · 2023Review
- Free-breathing 3D CEST MRI of human liver at 3.0 T.Magnetic resonance in medicine · 2023Article
- Liver MRI with amide proton transfer imaging: feasibility and accuracy for the characterization of focal liver lesions.European radiology · 2021Article
- Effectiveness of fat suppression using a water-selective binomial-pulse excitation in chemical exchange saturation transfer (CEST) magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
- MRI monitoring of energy storage in vivo using magnetization pathways.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using DynamicHepatology communications · 2020Article
- Magnetic resonance imaging of glycogen using its magnetic coupling with water.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Chemical exchange saturation transfer magnetic resonance imaging and its main and potential applications in pre-clinical and clinical studies.Quantitative imaging in medicine and surgery · 2019Review
- Amide proton transfer-weighted MRI for predicting histological grade of hepatocellular carcinoma: comparison with diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2019Article
- Sugar-based biopolymers as novel imaging agents for molecular magnetic resonance imaging.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
Corrections and comments
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6 authors.
Funding
Abstract
purposeThis study seeks to explore whether chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) can detect liver composition changes between after-meal and over-night-fast statuses. PROCEDURES: Fifteen healthy volunteers were scanned on a 3.0-T human MRI scanner in the evening 1.5-2 h after dinner and in the morning after over-night (12-h) fasting. Among them, seven volunteers were scanned twice to assess the scan-rescan reproducibility. Images were acquired at offsets (n = 41, increment = 0.25 ppm) from -5 to 5 ppm using a turbo spin echo (TSE) sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified with the asymmetric magnetization transfer ratio (MTRasym) at 3.5 ppm and the total MTRasym integrated from 0.5 to 1.5 ppm from the corrected Z-spectrum, respectively. To explore scan time reduction, CEST images were reconstructed using 31 offsets (with 20% time reduction) and 21 offsets (with 40% time reduction), respectively.
resultsFor reproducibility, GlycoCEST measurements in 41 offsets showed the smallest scan-rescan mean measurements variability, indicated by the lowest mean difference of -0.049% (95% limits of agreement, -0.209 to 0.111%); for APTw, the smallest mean difference was found to be 0.112% (95% limits of agreement, -0.698 to 0.921%) in 41 offsets. Compared with after-meal, both GlycoCEST measurement and APTw measurement under different offset number decreased after 12-h fasting. However, as the offsets number decreased (41 offsets vs. 31 offsets vs. 21 offsets), GlycoCEST map and APTw map became more heterogeneous and noisier.
conclusionOur results show that CEST liver imaging at 3.0 T has high sensitivity for fasting.
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