Evidence map›Paper›PMID 26391766›Full record

ArticleJournal of the International Neuropsychological Society : JINS2015

Early Cognitively Based Functional Limitations Predict Loss of Independence in Instrumental Activities of Daily Living in Older Adults.

Karen M Lau, Mili Parikh, Danielle J Harvey, Chun-Jung Huang, Sarah Tomaszewski Farias

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03549078 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized Evaluation of a Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia

TypeinterventionalSponsorUniversity of California, DavisRan2017 to 2019Enrolled69ConditionsFunctional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health ActivitiesArmsIntervention
NCT03717597 nacompletednot on this mapstarted 2018, after this paper: background citation

A Nonrandomized Evaluation of a Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia

TypeinterventionalSponsorUniversity of California, DavisRan2018 to 2021Enrolled15ConditionsSubjective Cognitive Concerns (SCC)ArmsIntervention
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. The relation between cognitive functioning and activities of daily living in normal aging, mild cognitive impairment, and dementia: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
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  10. Concurrent Validity of Performance-Based Measures of Daily Functioning with Cognitive Measures and Informant Reported Everyday Functioning.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  11. Social factors associated with everyday functioning in older Black adults.Journal of the International Neuropsychological Society : JINS · 2025
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  12. Article
  13. A short version of the Everyday Cognition scale can predict clinical progression and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Karen M Lau1San Francisco Veterans Affairs Medical Center,San Francisco,California.
Mili Parikh3Veterans Affairs Northern California Health Care System,Mather,California.
Danielle J Harvey4Division of Biostatistics,Department of Public Health Sciences,School of Medicine,University of California,Davis,Davis,California.
Chun-Jung Huang4Division of Biostatistics,Department of Public Health Sciences,School of Medicine,University of California,Davis,Davis,California.
Sarah Tomaszewski Farias2Department of Neurology,School of Medicine,University of California,Davis,Sacramento,California.
University of California, Davis · USSan Francisco VA Medical Center · USVA Northern California Health Care System · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYR01AG010220 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MUNGAS, DAN M. · 1992 to 2012
$4.5M
Brain pathologies, reserve and cognition in aging and dementiaRF1AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2015 to 2015
$3.8M
Understanding the Pathway to Functional Disability in Alzheimer's diseaseR01AG031252 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TOMASZEWSKI-FARIAS, SARAH E · 2008 to 2012
$1.8M
"MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"K01AG030514 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARMICHAEL, OWEN T. · 2008 to 2012
$495k
NIA NIH HHS AG031252NIA NIH HHS AG10129NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG010220NIA NIH HHS R01 AG031252NIA NIH HHS R01 AG031563NIA NIH HHS RF1 AG031563
6 · The paper itself

Abstract

Older adults with early forms of neurodegenerative disease are at risk for functional disability, which is often defined by the loss of independence in instrumental activities of daily living (IADLs). The current study investigated the influence of mild changes in everyday functional abilities (referred to as functional limitations) on risk for development of incident functional disability. A total of 407 participants, who were considered cognitively normal or diagnosed with mild cognitive impairment (MCI) at baseline, were followed longitudinally over an average 4.1 years (range=0.8-9.2 years). Informant-based ratings from the Everyday Cognition (ECog; Farias et al., 2008) and the Instrumental Activities of Daily Living (Lawton & Brody, 1969) scales assessed the degree of functional limitations and incident IADL disability, respectively. Cox proportional hazards models revealed that more severe functional limitations (as measured by the Total ECog score) at baseline were associated with approximately a four-fold increased risk of developing IADL disability a few years later. Among the ECog domains, functional limitations in Everyday Planning, Everyday Memory, and Everyday Visuospatial domains were associated with the greatest risk of incident functional disability. These results remained robust even after controlling for participants' neuropsychological functioning on tests of executive functions and episodic memory. Current findings indicate that early functional limitations have prognostic value in identifying older adults at risk for developing functional disability. Findings highlight the importance of developing interventions to support everyday abilities related to memory, executive function, and visuospatial skills in an effort to delay loss of independence in IADLs.

Indexed as

Activities of Daily LivingAgedCognitive DysfunctionDisability EvaluationFemaleHumansIndependent LivingLongitudinal StudiesMaleNeuropsychological TestsPrognosisAlzheimer’s diseaseCognitionDementiaDisabilityEveryday functionInstrumental activities of daily living

Identifiers

PMID26391766
PMCPMC5540650
OpenAlexW2270641217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.