ArticleScientific reports2015
Immunological Adaptations to Pregnancy in Women with Type 1 Diabetes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Tregs in pregnancy with type 1 diabetes mellitus: pilot study.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Immunometabolic adaptation in monocytes underpins functional changes during pregnancy.iScience · 2024Article
- Exposure to gestational diabetes mellitus increases subclinical inflammation mediated in part by obesity.Clinical and experimental immunology · 2024Article
- Diabetic Retinopathy during pregnancy in Hispanic women with latent Toxoplasma gondii infection.European journal of obstetrics, gynecology, and reproductive biology · 2024Article
- Review
- Evaluation of SARS-CoV-2 vaccination in pregnant and breastfeeding women.IJID regions · 2023Article
- Immunological evaluation of herbal extracts commonly used for treatment of mental diseases during pregnancy.Scientific reports · 2023Article
- Adverse pregnancy outcomes in Toxoplasma gondii seropositive Hispanic women.The journal of obstetrics and gynaecology research · 2023Article
- Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth.JCI insight · 2022Article
- Single-cell atlas of peripheral blood mononuclear cells from pregnant women.Clinical and translational medicine · 2022Article
- Article
- Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis.Frontiers in immunology · 2022Article
- Group B streptococcal infection of the genitourinary tract in pregnant and non-pregnant patients with diabetes mellitus: An immunocompromised host or something more?American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function.Frontiers in endocrinology · 2021Article
- Melatonin Hormone Acts on Cells of Maternal Blood and Placenta From Diabetic Mothers.Frontiers in physiology · 2021Article
- Th2-Immune Polarizing and Anti-Inflammatory Properties of Insulin Are Not Effective in Type 2 Diabetic Pregnancy.Journal of immunology research · 2020Article
- Maternal Immunological Adaptation During Normal Pregnancy.Frontiers in immunology · 2020Review
- Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?Clinical rheumatology · 2019Review
- The Immunogenetic Conundrum of Preeclampsia.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite adequate glycemic control, pregnancy outcome of women with type 1 diabetes (T1D) is still unfavorable as compared to healthy women. In a rat-model of T1D under normoglycemic conditions, adverse pregnancy outcome was also observed, which was associated with aberrant immunological adaptations to pregnancy. Because similar processes may occur in women with T1D we studied the systemic immune response in non-pregnant and pregnant women with and without T1D. The systemic immune response was assessed by using flow cytometry to evaluate the number and activational status of subpopulations of lymphocytes, Natural Killer cells and monocytes in peripheral blood of non-pregnant and pregnant women with and without T1D. An increased white blood cell count, an increased Th1/Th2 ratio, increased Natural Killer cell expression of CD335 and enhanced activation of intermediate and non-classical monocytes was observed in pregnant women with T1D vs. healthy pregnant women. Also, the pregnancy outcome (i.e. incidence of preterm delivery and macrosomia) of women with T1D was unfavorable as compared to healthy women. This study showed that in T1D, the immunological adaptations to pregnancy are disturbed. In addition to hyperglycemia, these different immunological adaptations may be responsible for the greater frequency of complications in pregnant women with T1D.
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