ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed.
- Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.Molecular neurobiology · 2020Trial
- Neurophysiological sensitivity in early childhood: EEG aperiodic slope moderates the association between maternal anxiety and child internalizing symptoms.Development and psychopathology · 2026Article
- Discrimination and C-reactive protein across the life course: Findings from three national US cohorts.Brain, behavior, and immunity · 2026Article
- A Bifactor Model of Childhood Adversity in a Longitudinal South African Birth Cohort Study.Assessment · 2026Article
- Early life stress enhances the association between residential nature exposure and fasting blood glucose.PloS one · 2026Article
- Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Beyond physical isolation: behavioral correlates and potential neurobiological mechanisms of functional social isolation.Frontiers in psychology · 2026Review
- Predictors of Environmental Sensitivity in Syrian refugee children.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- The moderating role of hippocampal volume in the association between emotional abuse and peer victimization in adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- From Womb to Mind: Prenatal Epigenetic Influences on Mental Health Disorders.International journal of molecular sciences · 2025Review
- Temperament and sex as moderating factors of the effects of exposure to maternal depression on telomere length in early childhood.Development and psychopathology · 2025Article
- Associations Among EEG Aperiodic Slope, Infant Temperament, and Maternal Anxiety/Depression Symptoms in Infancy.Psychophysiology · 2025Article
- Strengthening through adversity: The hormesis model in developmental psychopathology.Development and psychopathology · 2024Article
- The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis.Molecular psychiatry · 2024Article
- Psychosocial Disadvantage During Childhood and Midlife Health: NIMHD Social Epigenomics Program.JAMA network open · 2024Article
- Validity, Reliability, Accessibility, and Applicability of Young Children's Developmental Screening and Assessment Tools across Different Demographics: A Realist Review.Children (Basel, Switzerland) · 2024Review
- Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study.Developmental cognitive neuroscience · 2024Article
- A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy.Developmental psychobiology · 2024Article
- Effects of lockdowns on neurobiological and psychometric parameters in unipolar depression during the COVID-19 pandemic.Translational psychiatry · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A swiftly growing volume of literature, comprising both human and animal studies and employing both observational and experimental designs, has documented striking individual differences in neurobiological sensitivities to environmental circumstances within subgroups of study samples. This differential susceptibility to social and physical environments operates bidirectionally, in both adverse and beneficial contexts, and results in a minority subpopulation with remarkably poor or unusually positive trajectories of health and development, contingent upon the character of environmental conditions. Differences in contextual susceptibility appear to emerge in early development, as the interactive and adaptive product of genetic and environmental attributes. This paper surveys what is currently known of the mechanisms or mediators of differential susceptibility, at the levels of temperament and behavior, physiological systems, brain circuitry and neuronal function, and genetic and epigenetic variation. It concludes with the assertion that differential susceptibility is inherently grounded within processes of biological moderation, the complexities of which are at present only partially understood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.