ArticleBMC pediatrics2015
Prevalence of congenital defects including selected neural tube defects in Nepal: results from a health survey.
Article in BMC pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Congenital Genitourinary Anomaly Identification and Referral in Rural Nepal: A Qualitative Study on the Perspective of Female Community Health Volunteers.Health science reports · 2026Article
- The burden of neural tube defects in Southern Ethiopia: trends, hotspots, and public health implications.PeerJ · 2026Article
- Occipital encephalocele: Presentation of case.International journal of surgery case reports · 2023Article
- Metabolic Analysis of Methylenetetrahydrofolate Reductase Single Nucleotide Polymorphisms (MTHFR 677C<T and MTHFR 1298A<C), Serum Folate and Vitamin B12 in Neural Tube Defects.Indian journal of clinical biochemistry : IJCB · 2023Article
- Factors Influencing Undernutrition among Female Adolescent Students in Darchula District, Nepal.Nutrients · 2023Article
- Intra-amniotic mesenchymal stem cell therapy improves the amniotic fluid microenvironment in rat spina bifida aperta fetuses.Cell proliferation · 2023Article
- Antenatal care in Nepal: a qualitative study into missed opportunities in the first trimester.AJOG global reports · 2022Article
- Congenital Upper Limb Deficiency with Oligodactyly: A Case Report.JNMA; journal of the Nepal Medical Association · 2022Article
- [Occipital encephalocele and associated anomalies including bilateral eyelid coloboma, bilateral cleft lip/cleft palate, amniotic bands on the right leg with absence of toes on right and left feet at the University Clinics of Graben Butembo 2021: a case report].The Pan African medical journal · 2022Article
- Occipital Encephalocele with Multiple Birth Defects: A Case Report.JNMA; journal of the Nepal Medical Association · 2021Article
- An evaluation of obstetric ultrasound education program in Nepal using the RE-AIM framework.BMC medical education · 2021Article
- Intra-Amniotic Delivery of CRMP4 siRNA Improves Mesenchymal Stem Cell Therapy in a Rat Spina Bifida Model.Molecular therapy. Nucleic acids · 2020Article
- Mature brain tissue in the sacrococcygeal region.Journal of surgical case reports · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn resource-limited nations like Nepal, congenital defects, including neural tube defects (NTDs), have great public health impact. NTDs and a few other congenital defects can be prevented by micronutrient supplementation. Without proper research regarding such defects, it is difficult to assess the damage made to health and productivity. This study aims to investigate different congenital defects among children in Nepal.
methodsHousehold surveys and health camps were conducted from 2011 to 2012. Physical examination of women of reproductive age (15 to 49 years) was done in selected Village Development Committees of nine districts in three ecological regions of Nepal. Congenital defects, including NTDs, were examined in children (age 0 to 5 years) who were alive at the time of the survey. Data entry and analysis was performed by using SPSS version 11.5.
results21,111 women were interviewed and 27,201 children born to them were assessed. The prevalence of congenital defects was 52.0 (95% CI: 44.0-61.0) per 10,000 children. The prevalence of selected NTDs was 4.0 (95% CI: 2.0-7.0) per 10,000 children. Among the neural tube defects, encephalocele, myelomeningocele and dermal sinus were the major ones, having almost the same prevalence in the Hill and Terai regions. The majority of children with genital abnormalities (17.0 per 10,000 children; 95% CI: 10.0-28.0) and limb deformities (14.0 per 10,000 children; 95% CI: 8.0-24.0) were found in the Terai. The rate of congenital birth defects was higher in the regions where women were in poor health.
conclusionThere is high prevalence of congenital defects in Nepal. Since such defects add a burden to families and society, it is imperative that health policies addressing programs like supplementation, fortification and dietary diversification be implemented.
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