ReviewNeurobiology of learning and memory2016
Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease.
Review in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Delayed, transient, lateralized deficits in pattern separation and pattern completion after focal hippocampal irradiation in humans.Scientific reports · 2025Article
- Adult neurogenesis in the hippocampal dentate gyrus affects sparsely synchronized rhythms, associated with pattern separation and integration.Cognitive neurodynamics · 2024Article
- Effect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus.Cognitive neurodynamics · 2024Article
- Article
- Disynaptic effect of hilar cells on pattern separation in a spiking neural network of hippocampal dentate gyrus.Cognitive neurodynamics · 2022Article
- Hemisphere-specific spatial representation by hippocampal granule cells.Nature communications · 2022Article
- Population and individual firing behaviors in sparsely synchronized rhythms in the hippocampal dentate gyrus.Cognitive neurodynamics · 2022Article
- Combination Antiretroviral Therapy (cART) in Diabetes Exacerbates Diabetogenic Effects on Hippocampal Microstructure, Neurogenesis and Cytokine Perturbation in Male Sprague Dawley Rats.Diagnostics (Basel, Switzerland) · 2022Article
- AUTS2 Syndrome: Molecular Mechanisms and Model Systems.Frontiers in molecular neuroscience · 2022Review
- Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 KHippocampus · 2020Article
- Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats.Neuroscience insights · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.Hippocampus · 2019Article
- Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression.Scientific reports · 2017Article
- Age-related deficits in the mnemonic similarity task for objects and scenes.Behavioural brain research · 2017Article
- Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The dentate gyrus (DG) and area CA3 of the hippocampus are highly organized lamellar structures which have been implicated in specific cognitive functions such as pattern separation and pattern completion. Here we describe how the anatomical organization and physiology of the DG and CA3 are consistent with structures that perform pattern separation and completion. We then raise a new idea related to the complex circuitry of the DG and CA3 where CA3 pyramidal cell 'backprojections' play a potentially important role in the sparse firing of granule cells (GCs), considered important in pattern separation. We also propose that GC axons, the mossy fibers, already known for their highly specialized structure, have a dynamic function that imparts variance--'mossy fiber variance'--which is important to pattern separation and completion. Computational modeling is used to show that when a subset of GCs become 'dominant,' one consequence is loss of variance in the activity of mossy fiber axons and a reduction in pattern separation and completion in the model. Empirical data are then provided using an example of 'dominant' GCs--subsets of GCs that develop abnormally and have increased excitability. Notably, these abnormal GCs have been identified in animal models of disease where DG-dependent behaviors are impaired. Together these data provide insight into pattern separation and completion, and suggest that behavioral impairment could arise from dominance of a subset of GCs in the DG-CA3 network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.